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4IOO

Crystal Structure of the first bromodomain of BRD4 in complex with N-methyltrimethylacetamide

Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 301
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO A 302
ChainResidue
ATHR134
AILE138
ALYS160

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO A 303
ChainResidue
AGLN59
ALEU63
ALEU114
AASN117
AHOH422
AHOH490
AARG58

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO A 304
ChainResidue
AHIS77
AASN130
ATHR134
ALEU156
AHOH426
AHOH438
AHOH458

site_idAC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE EDO A 305
ChainResidue
ATRP81
APRO82
ALYS99
AILE146
AMET149
AHOH420
AHOH497
AHOH511

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE BAE A 306
ChainResidue
APHE83
ALEU92
ALEU94
ATYR139
AASN140
AILE146
AHOH419
AHOH519

site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE DMS A 307
ChainResidue
AASN140
AILE146
AHOH419

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues106
DetailsDomain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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