4INH
Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| D | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| E | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| E | 0006508 | biological_process | proteolysis |
| F | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| F | 0006508 | biological_process | proteolysis |
| G | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| G | 0006508 | biological_process | proteolysis |
| H | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| H | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMS A 201 |
| Chain | Residue |
| A | PRO3 |
| A | TRP6 |
| A | SER7 |
| A | LYS88 |
| G | TRP6 |
| G | SER7 |
| G | LYS88 |
| G | LEU94 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMS B 201 |
| Chain | Residue |
| B | SER7 |
| B | LYS88 |
| B | HOH310 |
| E | TRP6 |
| E | SER7 |
| E | LYS88 |
| E | HOH238 |
| B | TRP6 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS D 201 |
| Chain | Residue |
| C | TRP6 |
| C | SER7 |
| C | LYS88 |
| C | LEU94 |
| D | TRP6 |
| D | LYS88 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS H 201 |
| Chain | Residue |
| F | TRP6 |
| F | SER7 |
| F | LYS88 |
| H | TRP6 |
| H | SER7 |
| H | LYS88 |
| H | LEU94 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | ACT_SITE: For 3CLpro activity => ECO:0000255|PROSITE-ProRule:PRU00870, ECO:0000269|PubMed:16641296, ECO:0000269|PubMed:23365454 |
| Chain | Residue | Details |
| A | HIS30 | |
| D | HIS30 | |
| D | GLU54 | |
| D | CYS139 | |
| E | HIS30 | |
| E | GLU54 | |
| E | CYS139 | |
| F | HIS30 | |
| F | GLU54 | |
| F | CYS139 | |
| G | HIS30 | |
| A | GLU54 | |
| G | GLU54 | |
| G | CYS139 | |
| H | HIS30 | |
| H | GLU54 | |
| H | CYS139 | |
| A | CYS139 | |
| B | HIS30 | |
| B | GLU54 | |
| B | CYS139 | |
| C | HIS30 | |
| C | GLU54 | |
| C | CYS139 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | SITE: Cleavage; by 3CLpro => ECO:0000305|PubMed:17554035, ECO:0000305|PubMed:20976190 |
| Chain | Residue | Details |
| A | GLU181 | |
| B | GLU181 | |
| C | GLU181 | |
| D | GLU181 | |
| E | GLU181 | |
| F | GLU181 | |
| G | GLU181 | |
| H | GLU181 |
