4INH
Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| D | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| E | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| E | 0006508 | biological_process | proteolysis |
| F | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| F | 0006508 | biological_process | proteolysis |
| G | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| G | 0006508 | biological_process | proteolysis |
| H | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| H | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMS A 201 |
| Chain | Residue |
| A | PRO3 |
| A | TRP6 |
| A | SER7 |
| A | LYS88 |
| G | TRP6 |
| G | SER7 |
| G | LYS88 |
| G | LEU94 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMS B 201 |
| Chain | Residue |
| B | SER7 |
| B | LYS88 |
| B | HOH310 |
| E | TRP6 |
| E | SER7 |
| E | LYS88 |
| E | HOH238 |
| B | TRP6 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS D 201 |
| Chain | Residue |
| C | TRP6 |
| C | SER7 |
| C | LYS88 |
| C | LEU94 |
| D | TRP6 |
| D | LYS88 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS H 201 |
| Chain | Residue |
| F | TRP6 |
| F | SER7 |
| F | LYS88 |
| H | TRP6 |
| H | SER7 |
| H | LYS88 |
| H | LEU94 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Active site: {"description":"For 3CLpro activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00870","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16641296","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23365454","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Site: {"description":"Cleavage; by 3CLpro","evidences":[{"source":"PubMed","id":"17554035","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"20976190","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
