4IN9
Structure of karilysin MMP-like catalytic domain in complex with inhibitory tetrapeptide SWFP
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | HIS155 |
| A | HIS159 |
| A | HIS165 |
| B | SER1 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 302 |
| Chain | Residue |
| A | HIS102 |
| A | ASP104 |
| A | HIS117 |
| A | HIS133 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 303 |
| Chain | Residue |
| A | SER78 |
| A | LEU80 |
| A | HOH536 |
| A | HOH537 |
| A | HOH538 |
| A | SER75 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 304 |
| Chain | Residue |
| A | PHE108 |
| A | GOL307 |
| A | HOH427 |
| A | HOH478 |
| A | HOH548 |
| A | HOH595 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 305 |
| Chain | Residue |
| A | SER75 |
| A | SER81 |
| A | PHE82 |
| A | HOH438 |
| A | HOH535 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 306 |
| Chain | Residue |
| A | ALA118 |
| A | GLN183 |
| A | HOH569 |
| A | HOH594 |
| A | HOH605 |
| B | SER1 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 307 |
| Chain | Residue |
| A | ASP135 |
| A | ASP137 |
| A | GLU138 |
| A | NA304 |
| A | HOH596 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 308 |
| Chain | Residue |
| A | TYR52 |
| A | LYS94 |
| A | LYS96 |
| A | HIS131 |
| A | LEU132 |
| A | HIS133 |
| A | HOH547 |
| A | HOH600 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 309 |
| Chain | Residue |
| A | ASP104 |
| A | GLY105 |
| A | TYR128 |
| A | SER169 |
| A | SER170 |
| A | HOH487 |
| A | HOH513 |
| A | HOH580 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEIGHLL |
| Chain | Residue | Details |
| A | VAL152-LEU161 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21166898","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23695557","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21166898","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23695557","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
