Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019262 | biological_process | N-acetylneuraminate catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE NGF A 501 |
| Chain | Residue |
| A | ALA10 |
| A | PHE189 |
| A | ASP190 |
| A | GLU191 |
| A | GLY206 |
| A | SER207 |
| A | LEU250 |
| A | TYR251 |
| A | HOH833 |
| A | GLY46 |
| A | SER47 |
| A | THR48 |
| A | TYR136 |
| A | ILE138 |
| A | PHE140 |
| A | THR166 |
| A | GLY188 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ME2 A 502 |
| Chain | Residue |
| A | LYS112 |
| A | PHE140 |
| A | LEU141 |
| A | GLY143 |
| A | HOH779 |
| A | HOH790 |
| A | HOH892 |
| B | LYS112 |
| B | PHE140 |
| B | GLY143 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ME2 A 503 |
| Chain | Residue |
| A | THR129 |
| A | GLY130 |
| A | LYS159 |
| A | HOH841 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ME2 A 504 |
| Chain | Residue |
| A | HIS120 |
| A | GLU275 |
| A | SER278 |
| A | HOH740 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ME2 A 505 |
| Chain | Residue |
| A | VAL148 |
| A | TYR171 |
| A | LEU172 |
| A | ARG175 |
| A | GLU243 |
| A | HOH621 |
| A | HOH649 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ME2 A 506 |
| Chain | Residue |
| A | LEU246 |
| A | ALA247 |
| A | LYS280 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE NGF B 501 |
| Chain | Residue |
| B | ALA10 |
| B | TYR43 |
| B | GLY46 |
| B | SER47 |
| B | THR48 |
| B | TYR136 |
| B | ILE138 |
| B | THR166 |
| B | GLY188 |
| B | PHE189 |
| B | ASP190 |
| B | GLU191 |
| B | GLY206 |
| B | SER207 |
| B | LEU250 |
| B | TYR251 |
| B | HOH799 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ME2 B 502 |
| Chain | Residue |
| B | ILE146 |
| B | GLY147 |
| B | VAL148 |
| B | TYR171 |
| B | GLU243 |
| B | HOH663 |
| B | HOH926 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ME2 B 503 |
| Chain | Residue |
| B | ASN248 |
| B | SER277 |
| B | GLU279 |
| B | LYS280 |
| B | PHE283 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ME2 B 504 |
| Chain | Residue |
| B | ASP240 |
| B | PHE283 |
| B | GLU286 |
| B | LEU287 |
| B | LYS290 |
| B | TYR291 |
| B | HOH770 |
Functional Information from PROSITE/UniProt
| site_id | PS00217 |
| Number of Residues | 26 |
| Details | SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. VdGLYvGGstgenfmLstEekkeifR |
| Chain | Residue | Details |
| A | VAL39-ARG64 | |
| site_id | PS00665 |
| Number of Residues | 18 |
| Details | DHDPS_1 Dihydrodipicolinate synthase signature 1. GLYvgGSTGENfmlsteE |
| Chain | Residue | Details |
| A | GLY41-GLU58 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_01237","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Schiff-base intermediate with substrate","evidences":[{"source":"HAMAP-Rule","id":"MF_01237","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24152047","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24152047","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4IMF","evidenceCode":"ECO:0007744"}]} |
