4IKU
Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with 2-((5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)amino)-3-phenylpropanamide
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SHX A 401 |
| Chain | Residue |
| A | TYR195 |
| A | HOH567 |
| A | HOH660 |
| A | TYR196 |
| A | CYS203 |
| A | HIS212 |
| A | TYR300 |
| A | HIS310 |
| A | TRP353 |
| A | CO404 |
| A | HOH501 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CO A 402 |
| Chain | Residue |
| A | ASP240 |
| A | HIS303 |
| A | THR334 |
| A | GLU336 |
| A | GLU367 |
| A | CO403 |
| A | HOH578 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CO A 403 |
| Chain | Residue |
| A | ASP229 |
| A | ASP240 |
| A | GLU367 |
| A | CO402 |
| A | HOH528 |
| A | HOH578 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO A 404 |
| Chain | Residue |
| A | HIS212 |
| A | SHX401 |
| A | HOH501 |
| A | HOH530 |
| A | HOH549 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 405 |
| Chain | Residue |
| A | SER205 |
| A | ASN207 |
| A | VAL209 |
| A | SER363 |
| A | HOH513 |
Functional Information from PROSITE/UniProt
| site_id | PS00680 |
| Number of Residues | 19 |
| Details | MAP_1 Methionine aminopeptidase subfamily 1 signature. YcGHGIHklfHtapnVp.HY |
| Chain | Residue | Details |
| A | TYR300-TYR318 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03174","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16724298","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16823043","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17114291","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03174","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16274222","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16724298","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16823043","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17114291","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
