Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4IKP

Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin

Functional Information from GO Data
ChainGOidnamespacecontents
A0016274molecular_functionprotein-arginine N-methyltransferase activity
A0018216biological_processpeptidyl-arginine methylation
B0016274molecular_functionprotein-arginine N-methyltransferase activity
B0018216biological_processpeptidyl-arginine methylation
C0016274molecular_functionprotein-arginine N-methyltransferase activity
C0018216biological_processpeptidyl-arginine methylation
D0016274molecular_functionprotein-arginine N-methyltransferase activity
D0018216biological_processpeptidyl-arginine methylation
Functional Information from PDB Data
site_idAC1
Number of Residues27
DetailsBINDING SITE FOR RESIDUE 4IK A 501
ChainResidue
ATYR149
ASER195
AILE197
AGLU214
AALA215
AGLY240
ALYS241
AVAL242
AGLU243
AGLU257
AMET268
APHE150
ASER271
AGOL502
AHOH615
AHOH617
AHOH667
AHOH745
AHOH777
AHOH784
ATYR153
AGLN159
AMET162
AARG168
AGLY192
ACYS193
AGLY194

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL A 502
ChainResidue
ATYR149
AGLU266
AARG267
AMET268
ASER271
AGLN446
A4IK501
AHOH662

site_idAC3
Number of Residues24
DetailsBINDING SITE FOR RESIDUE 4IK B 501
ChainResidue
BTYR149
BPHE150
BTYR153
BGLN159
BMET162
BARG168
BGLY192
BCYS193
BGLY194
BILE197
BLEU198
BGLU214
BALA215
BGLY240
BLYS241
BVAL242
BGLU243
BGLU257
BMET268
BSER271
BHOH604
BHOH605
BHOH628
BHOH751

site_idAC4
Number of Residues24
DetailsBINDING SITE FOR RESIDUE 4IK C 501
ChainResidue
CTYR149
CPHE150
CTYR153
CGLN159
CMET162
CARG168
CGLY192
CCYS193
CSER195
CILE197
CLEU198
CGLU214
CALA215
CGLY240
CLYS241
CVAL242
CGLU243
CGLU257
CMET268
CSER271
CGOL503
CHOH601
CHOH604
CHOH753

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL C 502
ChainResidue
CHIS293
CSER352
CHOH684

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL C 503
ChainResidue
CTYR149
CGLU266
CMET268
CSER271
CGLN446
C4IK501
CGOL504

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL C 504
ChainResidue
CARG267
CGLU364
CGLN446
CGOL503
CHOH779

site_idAC8
Number of Residues24
DetailsBINDING SITE FOR RESIDUE 4IK D 501
ChainResidue
DPHE150
DTYR153
DGLN159
DMET162
DARG168
DGLY192
DCYS193
DGLY194
DILE197
DLEU198
DGLU214
DALA215
DGLY240
DLYS241
DVAL242
DGLU243
DGLU257
DMET268
DSER271
DGOL502
DHOH602
DHOH613
DHOH616
DTYR149

site_idAC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL D 502
ChainResidue
DGLU266
DARG267
DSER271
D4IK501

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsBINDING: BINDING => ECO:0000305|PubMed:21410432
ChainResidueDetails
AGLN159
BGLU214
BGLU243
BSER271
CGLN159
CARG168
CGLY192
CGLU214
CGLU243
CSER271
DGLN159
AARG168
DARG168
DGLY192
DGLU214
DGLU243
DSER271
AGLY192
AGLU214
AGLU243
ASER271
BGLN159
BARG168
BGLY192

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:19843527
ChainResidueDetails
ASER216
BSER216
CSER216
DSER216

site_idSWS_FT_FI3
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:34480022
ChainResidueDetails
ALYS227
BLYS227
CLYS227
DLYS227

226707

PDB entries from 2024-10-30

PDB statisticsPDBj update infoContact PDBjnumon