4IK0
Crystal structure of diaminopimelate epimerase Y268A mutant from Escherichia coli
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008047 | molecular_function | enzyme activator activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0008837 | molecular_function | diaminopimelate epimerase activity |
| A | 0009085 | biological_process | lysine biosynthetic process |
| A | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008047 | molecular_function | enzyme activator activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0008837 | molecular_function | diaminopimelate epimerase activity |
| B | 0009085 | biological_process | lysine biosynthetic process |
| B | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 301 |
| Chain | Residue |
| A | CYS79 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 303 |
| Chain | Residue |
| A | ARG78 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 304 |
| Chain | Residue |
| A | ALA171 |
| A | LEU175 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 305 |
| Chain | Residue |
| A | HIS201 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 302 |
| Chain | Residue |
| B | ASN133 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 303 |
| Chain | Residue |
| B | ASN11 |
| B | ARG78 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 304 |
| Chain | Residue |
| B | ALA171 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 305 |
| Chain | Residue |
| B | VAL105 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 306 |
| Chain | Residue |
| B | HIS201 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 307 |
| Chain | Residue |
| B | HIS37 |
Functional Information from PROSITE/UniProt
| site_id | PS01326 |
| Number of Residues | 15 |
| Details | DAP_EPIMERASE Diaminopimelate epimerase signature. NaDGSevaqCGNGaR |
| Chain | Residue | Details |
| A | ASN64-ARG78 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00197 |
| Chain | Residue | Details |
| A | CYS73 | |
| B | CYS73 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00197 |
| Chain | Residue | Details |
| A | CYS217 | |
| B | CYS217 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00197 |
| Chain | Residue | Details |
| A | ASN11 | |
| B | GLN44 | |
| B | ASN64 | |
| B | GLY74 | |
| B | ASN157 | |
| B | ASN190 | |
| B | GLU208 | |
| B | GLY218 | |
| A | GLN44 | |
| A | ASN64 | |
| A | GLY74 | |
| A | ASN157 | |
| A | ASN190 | |
| A | GLU208 | |
| A | GLY218 | |
| B | ASN11 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Could be important to modulate the pK values of the two catalytic cysteine residues => ECO:0000255|HAMAP-Rule:MF_00197 |
| Chain | Residue | Details |
| A | HIS159 | |
| A | GLU208 | |
| B | HIS159 | |
| B | GLU208 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Important for dimerization => ECO:0000269|PubMed:23426375 |
| Chain | Residue | Details |
| A | ALA268 | |
| B | ALA268 |
