4IJZ
Crystal structure of diaminopimelate epimerase from Escherichia coli
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008047 | molecular_function | enzyme activator activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0008837 | molecular_function | diaminopimelate epimerase activity |
| A | 0009085 | biological_process | lysine biosynthetic process |
| A | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008047 | molecular_function | enzyme activator activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0008837 | molecular_function | diaminopimelate epimerase activity |
| B | 0009085 | biological_process | lysine biosynthetic process |
| B | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NO3 A 301 |
| Chain | Residue |
| A | ALA132 |
| A | ASN133 |
| A | LYS134 |
| A | TYR139 |
| A | ARG184 |
| A | HOH516 |
| B | PHE24 |
| B | PHE25 |
| B | SER26 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NO3 A 302 |
| Chain | Residue |
| A | VAL23 |
| A | GLU49 |
| A | HOH437 |
| B | ARG142 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE NO3 B 301 |
| Chain | Residue |
| A | PHE24 |
| A | PHE25 |
| A | SER26 |
| B | ALA132 |
| B | ASN133 |
| B | LYS134 |
| B | TYR139 |
| B | ARG184 |
| B | HOH427 |
| B | HOH551 |
Functional Information from PROSITE/UniProt
| site_id | PS01326 |
| Number of Residues | 15 |
| Details | DAP_EPIMERASE Diaminopimelate epimerase signature. NaDGSevaqCGNGaR |
| Chain | Residue | Details |
| A | ASN64-ARG78 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_00197","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00197","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00197","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Could be important to modulate the pK values of the two catalytic cysteine residues","evidences":[{"source":"HAMAP-Rule","id":"MF_00197","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for dimerization","evidences":[{"source":"PubMed","id":"23426375","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
