4IJT

Human p53 core domain with hot spot mutation R273H (form II)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006915	biological_process	apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	CYS176
A	HIS179
A	CYS238
A	CYS242

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 302

Chain	Residue
A	HIS115
A	CYS182
A	DTT303

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DTT A 303

Chain	Residue
A	HOH495
A	HOH622
A	SER183
A	ZN302

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 304

Chain	Residue
A	LEU114
A	LEU264
A	ARG267
A	HOH426
A	HOH533
A	HOH558
A	HOH604

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE EDO A 305

Chain	Residue
A	TYR103
A	GLN104
A	GLY105
A	GLY108
A	THR231
A	HIS233
A	HOH410
A	HOH411
A	HOH424
A	HOH478
A	HOH496
A	HOH517
A	HOH607

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 306

Chain	Residue
A	LEU114
A	SER116
A	CYS124
A	PRO142
A	HOH414
A	HOH530
A	HOH536
A	HOH542

---

Functional Information from PROSITE/UniProt

site_id	PS00348
Number of Residues	13
Details	P53 p53 family signature. MCNSSCMGGMNRR

Chain	Residue	Details
A	MET237-ARG249

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	190
Details	DNA_BIND: DNA_BIND => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130

Chain	Residue	Details
A	THR102-LYS292

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130

Chain	Residue	Details
A	CYS176
A	HIS179
A	CYS238
A	CYS242

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Interaction with DNA => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130

Chain	Residue	Details
A	LYS120

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:23431171

Chain	Residue	Details
A	LYS120

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462

Chain	Residue	Details
A	SER183
A	SER269

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462

Chain	Residue	Details
A	THR284

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19536131

Chain	Residue	Details
A	LYS291
A	LYS292

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