4IJR

Crystal structure of Saccharomyces cerevisiae arabinose dehydrogenase Ara1 complexed with NADPH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004032	molecular_function	aldose reductase (NADPH) activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0045149	biological_process	acetoin metabolic process
A	0045290	molecular_function	D-arabinose 1-dehydrogenase [NAD(P)+] activity
A	0047816	molecular_function	D-arabinose 1-dehydrogenase (NAD+) activity
A	0052588	molecular_function	diacetyl reductase ((S)-acetoin forming) (NAD+) activity
A	0106271	molecular_function	D-arabinose 1-dehydrogenase (NADP+) activity
C	0004032	molecular_function	aldose reductase (NADPH) activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0045149	biological_process	acetoin metabolic process
C	0045290	molecular_function	D-arabinose 1-dehydrogenase [NAD(P)+] activity
C	0047816	molecular_function	D-arabinose 1-dehydrogenase (NAD+) activity
C	0052588	molecular_function	diacetyl reductase ((S)-acetoin forming) (NAD+) activity
C	0106271	molecular_function	D-arabinose 1-dehydrogenase (NADP+) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NDP A 401

Chain	Residue
A	GLY39
A	TYR240
A	SER241
A	PRO242
A	LEU243
A	GLY244
A	SER245
A	ALA248
A	LEU251
A	ASN268
A	ILE283
A	THR40
A	PRO284
A	ARG285
A	SER286
A	LEU287
A	ARG291
A	HOH586
A	HOH594
A	ALA41
A	ASP66
A	TYR71
A	HIS131
A	SER192
A	ASN193
A	GLN214

---

site_id	AC2
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NDP C 401

Chain	Residue
C	GLY39
C	THR40
C	ALA41
C	ASP66
C	TYR71
C	HIS131
C	TRP132
C	SER192
C	ASN193
C	GLN214
C	TYR240
C	SER241
C	PRO242
C	LEU243
C	GLY244
C	SER245
C	ALA248
C	LEU251
C	ASN268
C	ILE283
C	PRO284
C	ARG285
C	SER286
C	LEU287
C	ARG291
C	HOH617

---

Functional Information from PROSITE/UniProt

site_id	PS00062
Number of Residues	18
Details	ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. IyldpndhrVRAIGVSNF

Chain	Residue	Details
A	ILE177-PHE194

---

site_id	PS00063
Number of Residues	16
Details	ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPRSLNpvRIsSSiEF

Chain	Residue	Details
A	ILE283-PHE298

---

site_id	PS00798
Number of Residues	18
Details	ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHIDTAwayetEpfVG

Chain	Residue	Details
A	GLY61-GLY78

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	110
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Lowers pKa of active site Tyr","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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