4IJR
Crystal structure of Saccharomyces cerevisiae arabinose dehydrogenase Ara1 complexed with NADPH
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004032 | molecular_function | aldose reductase (NADPH) activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0045149 | biological_process | acetoin metabolic process |
A | 0045290 | molecular_function | D-arabinose 1-dehydrogenase [NAD(P)+] activity |
A | 0047816 | molecular_function | D-arabinose 1-dehydrogenase (NAD+) activity |
A | 0052588 | molecular_function | diacetyl reductase ((S)-acetoin forming) (NAD+) activity |
A | 0106271 | molecular_function | D-arabinose 1-dehydrogenase (NADP+) activity |
C | 0004032 | molecular_function | aldose reductase (NADPH) activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0005975 | biological_process | carbohydrate metabolic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0045149 | biological_process | acetoin metabolic process |
C | 0045290 | molecular_function | D-arabinose 1-dehydrogenase [NAD(P)+] activity |
C | 0047816 | molecular_function | D-arabinose 1-dehydrogenase (NAD+) activity |
C | 0052588 | molecular_function | diacetyl reductase ((S)-acetoin forming) (NAD+) activity |
C | 0106271 | molecular_function | D-arabinose 1-dehydrogenase (NADP+) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE NDP A 401 |
Chain | Residue |
A | GLY39 |
A | TYR240 |
A | SER241 |
A | PRO242 |
A | LEU243 |
A | GLY244 |
A | SER245 |
A | ALA248 |
A | LEU251 |
A | ASN268 |
A | ILE283 |
A | THR40 |
A | PRO284 |
A | ARG285 |
A | SER286 |
A | LEU287 |
A | ARG291 |
A | HOH586 |
A | HOH594 |
A | ALA41 |
A | ASP66 |
A | TYR71 |
A | HIS131 |
A | SER192 |
A | ASN193 |
A | GLN214 |
site_id | AC2 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE NDP C 401 |
Chain | Residue |
C | GLY39 |
C | THR40 |
C | ALA41 |
C | ASP66 |
C | TYR71 |
C | HIS131 |
C | TRP132 |
C | SER192 |
C | ASN193 |
C | GLN214 |
C | TYR240 |
C | SER241 |
C | PRO242 |
C | LEU243 |
C | GLY244 |
C | SER245 |
C | ALA248 |
C | LEU251 |
C | ASN268 |
C | ILE283 |
C | PRO284 |
C | ARG285 |
C | SER286 |
C | LEU287 |
C | ARG291 |
C | HOH617 |
Functional Information from PROSITE/UniProt
site_id | PS00062 |
Number of Residues | 18 |
Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. IyldpndhrVRAIGVSNF |
Chain | Residue | Details |
A | ILE177-PHE194 |
site_id | PS00063 |
Number of Residues | 16 |
Details | ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPRSLNpvRIsSSiEF |
Chain | Residue | Details |
A | ILE283-PHE298 |
site_id | PS00798 |
Number of Residues | 18 |
Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHIDTAwayetEpfVG |
Chain | Residue | Details |
A | GLY61-GLY78 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor => ECO:0000250 |
Chain | Residue | Details |
A | TYR71 | |
C | TYR71 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | HIS131 | |
A | SER241 | |
C | HIS131 | |
C | SER241 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | SITE: Lowers pKa of active site Tyr => ECO:0000250 |
Chain | Residue | Details |
A | LYS100 | |
C | LYS100 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956 |
Chain | Residue | Details |
A | THR151 | |
C | THR151 |