4IJD
Crystal structure of methyltransferase domain of human PR domain-containing protein 9
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 501 |
| Chain | Residue |
| A | CYS205 |
| A | CYS208 |
| A | CYS216 |
| A | HIS219 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 502 |
| Chain | Residue |
| A | CYS390 |
| A | CYS393 |
| A | HIS406 |
| A | HIS411 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 501 |
| Chain | Residue |
| B | CYS208 |
| B | CYS216 |
| B | HIS219 |
| B | CYS205 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 502 |
| Chain | Residue |
| B | CYS390 |
| B | CYS393 |
| B | HIS406 |
| B | HIS411 |
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 22 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cps..CclaFssqkflsqHvern.H |
| Chain | Residue | Details |
| A | CYS390-HIS411 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24095733","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2019","submissionDatabase":"PDB data bank","title":"Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor.","authors":["Ivanochko D.","Halabelian L.","Fischer C.","Sanders J.M.","Kattar S.D.","Brown P.J.","Edwards A.M.","Bountra C.","Arrowsmith C.H."]}},{"source":"PDB","id":"4IJD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NM4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2019","submissionDatabase":"PDB data bank","title":"Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor.","authors":["Ivanochko D.","Halabelian L.","Fischer C.","Sanders J.M.","Kattar S.D.","Brown P.J.","Edwards A.M.","Bountra C.","Arrowsmith C.H."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q96EQ9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24095733","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4IJD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q96EQ9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"Q96EQ9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
