4IJD

Crystal structure of methyltransferase domain of human PR domain-containing protein 9

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0042054	molecular_function	histone methyltransferase activity
B	0008270	molecular_function	zinc ion binding
B	0042054	molecular_function	histone methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	CYS205
A	CYS208
A	CYS216
A	HIS219

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	CYS390
A	CYS393
A	HIS406
A	HIS411

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 501

Chain	Residue
B	CYS208
B	CYS216
B	HIS219
B	CYS205

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 502

Chain	Residue
B	CYS390
B	CYS393
B	HIS406
B	HIS411

---

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	22
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cps..CclaFssqkflsqHvern.H

Chain	Residue	Details
A	CYS390-HIS411

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	46
Details	ZN_FING: C2H2-type 1 => ECO:0000255|PROSITE-ProRule:PRU00042

Chain	Residue	Details
A	HIS388-HIS411
B	HIS388-HIS411

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:24095733, ECO:0000269|Ref.10, ECO:0007744|PDB:4IJD, ECO:0007744|PDB:6NM4

Chain	Residue	Details
A	CYS205
A	CYS208
A	CYS216
A	HIS219
B	CYS205
B	CYS208
B	CYS216
B	HIS219

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|Ref.10

Chain	Residue	Details
A	ALA256
A	TYR291
A	ASN320
B	ALA256
B	TYR291
B	ASN320

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q96EQ9

Chain	Residue	Details
A	ASN288
A	TYR357
B	ASN288
B	TYR357

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:24095733, ECO:0007744|PDB:4IJD

Chain	Residue	Details
A	CYS390
A	CYS393
A	HIS406
A	HIS411
B	CYS390
B	CYS393
B	HIS406
B	HIS411

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:Q96EQ9

Chain	Residue	Details
A	LYS368
B	LYS368

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:Q96EQ9

Chain	Residue	Details
A	LYS372
A	LYS374
B	LYS372
B	LYS374

---