4IJC
Crystal structure of arabinose dehydrogenase Ara1 from Saccharomyces cerevisiae
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0045149 | biological_process | acetoin metabolic process |
| A | 0045290 | molecular_function | D-arabinose 1-dehydrogenase [NAD(P)+] activity |
| A | 0047816 | molecular_function | D-arabinose 1-dehydrogenase (NAD+) activity |
| A | 0052588 | molecular_function | diacetyl reductase ((S)-acetoin forming) (NAD+) activity |
| A | 0106271 | molecular_function | D-arabinose 1-dehydrogenase (NADP+) activity |
| B | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0045149 | biological_process | acetoin metabolic process |
| B | 0045290 | molecular_function | D-arabinose 1-dehydrogenase [NAD(P)+] activity |
| B | 0047816 | molecular_function | D-arabinose 1-dehydrogenase (NAD+) activity |
| B | 0052588 | molecular_function | diacetyl reductase ((S)-acetoin forming) (NAD+) activity |
| B | 0106271 | molecular_function | D-arabinose 1-dehydrogenase (NADP+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 401 |
| Chain | Residue |
| A | SER241 |
| A | SER245 |
| A | ARG285 |
| A | SO4402 |
| A | HOH530 |
| A | HOH628 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 402 |
| Chain | Residue |
| A | GLY244 |
| A | ARG285 |
| A | SO4401 |
| A | HOH629 |
| A | SER241 |
| A | PRO242 |
| A | LEU243 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 403 |
| Chain | Residue |
| A | VAL31 |
| A | ARG187 |
| A | HOH637 |
| A | HOH665 |
| B | LYS91 |
| B | HOH628 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B 401 |
| Chain | Residue |
| B | SER241 |
| B | PRO242 |
| B | LEU243 |
| B | GLY244 |
| B | SER245 |
| B | ARG285 |
| B | SO4402 |
| B | HOH552 |
| B | HOH592 |
| B | HOH634 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 402 |
| Chain | Residue |
| B | SER241 |
| B | SER245 |
| B | ARG285 |
| B | SO4401 |
Functional Information from PROSITE/UniProt
| site_id | PS00062 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. IyldpndhrVRAIGVSNF |
| Chain | Residue | Details |
| A | ILE177-PHE194 |
| site_id | PS00063 |
| Number of Residues | 16 |
| Details | ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPRSLNpvRIsSSiEF |
| Chain | Residue | Details |
| A | ILE283-PHE298 |
| site_id | PS00798 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHIDTAwayetEpfVG |
| Chain | Residue | Details |
| A | GLY61-GLY78 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 110 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Lowers pKa of active site Tyr","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
