4IJC

Crystal structure of arabinose dehydrogenase Ara1 from Saccharomyces cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004032	molecular_function	aldose reductase (NADPH) activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0045149	biological_process	acetoin metabolic process
A	0045290	molecular_function	D-arabinose 1-dehydrogenase [NAD(P)+] activity
A	0047816	molecular_function	D-arabinose 1-dehydrogenase (NAD+) activity
A	0052588	molecular_function	diacetyl reductase ((S)-acetoin forming) (NAD+) activity
A	0106271	molecular_function	D-arabinose 1-dehydrogenase (NADP+) activity
B	0004032	molecular_function	aldose reductase (NADPH) activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0045149	biological_process	acetoin metabolic process
B	0045290	molecular_function	D-arabinose 1-dehydrogenase [NAD(P)+] activity
B	0047816	molecular_function	D-arabinose 1-dehydrogenase (NAD+) activity
B	0052588	molecular_function	diacetyl reductase ((S)-acetoin forming) (NAD+) activity
B	0106271	molecular_function	D-arabinose 1-dehydrogenase (NADP+) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 401

Chain	Residue
A	SER241
A	SER245
A	ARG285
A	SO4402
A	HOH530
A	HOH628

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 402

Chain	Residue
A	GLY244
A	ARG285
A	SO4401
A	HOH629
A	SER241
A	PRO242
A	LEU243

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 403

Chain	Residue
A	VAL31
A	ARG187
A	HOH637
A	HOH665
B	LYS91
B	HOH628

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 B 401

Chain	Residue
B	SER241
B	PRO242
B	LEU243
B	GLY244
B	SER245
B	ARG285
B	SO4402
B	HOH552
B	HOH592
B	HOH634

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 402

Chain	Residue
B	SER241
B	SER245
B	ARG285
B	SO4401

---

Functional Information from PROSITE/UniProt

site_id	PS00062
Number of Residues	18
Details	ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. IyldpndhrVRAIGVSNF

Chain	Residue	Details
A	ILE177-PHE194

---

site_id	PS00063
Number of Residues	16
Details	ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPRSLNpvRIsSSiEF

Chain	Residue	Details
A	ILE283-PHE298

---

site_id	PS00798
Number of Residues	18
Details	ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHIDTAwayetEpfVG

Chain	Residue	Details
A	GLY61-GLY78

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000250

Chain	Residue	Details
A	TYR71
B	TYR71

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	HIS131
A	SER241
B	HIS131
B	SER241

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Lowers pKa of active site Tyr => ECO:0000250

Chain	Residue	Details
A	LYS100
B	LYS100

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956

Chain	Residue	Details
A	THR151
B	THR151

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