4IIN
Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from Helicobacter pylori 26695 complexed with NAD+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0051287 | molecular_function | NAD binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0051287 | molecular_function | NAD binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE NAD A 301 |
| Chain | Residue |
| A | GLY12 |
| A | ASN90 |
| A | ALA91 |
| A | GLY92 |
| A | ASN113 |
| A | VAL140 |
| A | ALA141 |
| A | SER142 |
| A | TYR155 |
| A | LYS159 |
| A | PRO185 |
| A | LYS15 |
| A | GLY186 |
| A | ILE188 |
| A | THR190 |
| A | HOH403 |
| A | HOH442 |
| C | GLU52 |
| A | GLY16 |
| A | ILE17 |
| A | GLY18 |
| A | ASN35 |
| A | ARG37 |
| A | ASP63 |
| A | ALA64 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 302 |
| Chain | Residue |
| A | GLU237 |
| A | THR238 |
| D | GLU237 |
| D | THR238 |
| D | HOH410 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NAD B 301 |
| Chain | Residue |
| B | LYS15 |
| B | GLY16 |
| B | ILE17 |
| B | ASN35 |
| B | ARG37 |
| B | ASP63 |
| B | ALA64 |
| B | ASN90 |
| B | ALA91 |
| B | GLY92 |
| B | ASN113 |
| B | VAL140 |
| B | ALA141 |
| B | TYR155 |
| B | LYS159 |
| B | PRO185 |
| B | GLY186 |
| B | ILE188 |
| B | ACT303 |
| B | HOH406 |
| B | HOH415 |
| B | HOH418 |
| B | HOH431 |
| B | HOH435 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 302 |
| Chain | Residue |
| B | GLU237 |
| B | THR238 |
| C | GLU237 |
| C | THR238 |
| C | HOH420 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT B 303 |
| Chain | Residue |
| B | SER142 |
| B | TYR155 |
| B | GLY186 |
| B | PHE187 |
| B | NAD301 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE NAD C 301 |
| Chain | Residue |
| C | GLY12 |
| C | GLY16 |
| C | ILE17 |
| C | ASN35 |
| C | ARG37 |
| C | ASP63 |
| C | ALA64 |
| C | ASN90 |
| C | GLY92 |
| C | VAL93 |
| C | ASN113 |
| C | ALA141 |
| C | SER142 |
| C | TYR155 |
| C | LYS159 |
| C | PRO185 |
| C | GLY186 |
| C | ILE188 |
| C | ACT302 |
| C | HOH411 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT C 302 |
| Chain | Residue |
| C | SER142 |
| C | TYR155 |
| C | PHE187 |
| C | NAD301 |
| site_id | AC8 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE NAD D 301 |
| Chain | Residue |
| D | ASN113 |
| D | VAL140 |
| D | ALA141 |
| D | TYR155 |
| D | LYS159 |
| D | PRO185 |
| D | GLY186 |
| D | ILE188 |
| D | THR190 |
| D | ACT302 |
| D | HOH415 |
| D | GLY12 |
| D | LYS15 |
| D | GLY16 |
| D | ILE17 |
| D | ASN35 |
| D | ARG37 |
| D | ASP63 |
| D | ALA64 |
| D | ASN90 |
| D | GLY92 |
| D | VAL93 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT D 302 |
| Chain | Residue |
| D | SER142 |
| D | TYR155 |
| D | GLY186 |
| D | NAD301 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SiigergnmgQtnYSASKGGMiAMSkSFA |
| Chain | Residue | Details |
| A | SER142-ALA170 |
