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4IE7

Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with citrate and rhein (RHN)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001659biological_processtemperature homeostasis
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006307biological_processDNA alkylation repair
A0008198molecular_functionferrous iron binding
A0010883biological_processregulation of lipid storage
A0016180biological_processsnRNA processing
A0016607cellular_componentnuclear speck
A0016706molecular_function2-oxoglutarate-dependent dioxygenase activity
A0016740molecular_functiontransferase activity
A0035515molecular_functionoxidative RNA demethylase activity
A0035516molecular_functionbroad specificity oxidative DNA demethylase activity
A0040014biological_processregulation of multicellular organism growth
A0042245biological_processRNA repair
A0043231cellular_componentintracellular membrane-bounded organelle
A0044065biological_processregulation of respiratory system process
A0046872molecular_functionmetal ion binding
A0051213molecular_functiondioxygenase activity
A0060612biological_processadipose tissue development
A0061157biological_processmRNA destabilization
A0070350biological_processregulation of white fat cell proliferation
A0090335biological_processregulation of brown fat cell differentiation
A1990931molecular_functionmRNA N6-methyladenosine dioxygenase activity
A1990984molecular_functiontRNA demethylase activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 601
ChainResidue
AHIS231
AASP233
AHIS307
AFLC603

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE RHN A 602
ChainResidue
ASER229
AHIS231
AHIS232
AASP233
AGLU234
AARG322
AFLC603
AARG96
ATYR106
ATYR108
ALEU109
AVAL228

site_idAC3
Number of Residues15
DetailsBINDING SITE FOR RESIDUE FLC A 603
ChainResidue
AARG96
AASN205
AVAL228
AHIS231
AASP233
AVAL244
ATYR295
AHIS307
AVAL309
AARG316
ASER318
ATHR320
AARG322
AZN601
ARHN602

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:20376003, ECO:0007744|PDB:3LFM
ChainResidueDetails
AARG96
ATYR108
ATHR320

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:25452335, ECO:0007744|PDB:3LFM, ECO:0007744|PDB:4QKN
ChainResidueDetails
AASN205

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:25452335, ECO:0000305|PubMed:23547775, ECO:0000305|PubMed:25452335, ECO:0000305|PubMed:26457839, ECO:0000305|PubMed:28553460, ECO:0007744|PDB:3LFM, ECO:0007744|PDB:4CXW, ECO:0007744|PDB:4CXX, ECO:0007744|PDB:4CXY, ECO:0007744|PDB:4IDZ, ECO:0007744|PDB:4IE0, ECO:0007744|PDB:4IE4, ECO:0007744|PDB:4IE5, ECO:0007744|PDB:4IE6, ECO:0007744|PDB:4IE7, ECO:0007744|PDB:4QKN, ECO:0007744|PDB:4ZS2, ECO:0007744|PDB:4ZS3
ChainResidueDetails
AHIS231

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:20376003, ECO:0000305|PubMed:23547775, ECO:0000305|PubMed:25452335, ECO:0000305|PubMed:26457839, ECO:0000305|PubMed:28553460, ECO:0007744|PDB:3LFM, ECO:0007744|PDB:4CXW, ECO:0007744|PDB:4CXX, ECO:0007744|PDB:4CXY, ECO:0007744|PDB:4IDZ, ECO:0007744|PDB:4IE0, ECO:0007744|PDB:4IE4, ECO:0007744|PDB:4IE5, ECO:0007744|PDB:4IE6, ECO:0007744|PDB:4IE7, ECO:0007744|PDB:4QKN, ECO:0007744|PDB:4ZS2, ECO:0007744|PDB:4ZS3
ChainResidueDetails
AASP233
AHIS307

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26457839, ECO:0007744|PDB:3LFM, ECO:0007744|PDB:4QKN, ECO:0007744|PDB:4ZS2, ECO:0007744|PDB:4ZS3
ChainResidueDetails
ATYR295
AARG316

site_idSWS_FT_FI6
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26457839, ECO:0007744|PDB:3LFM, ECO:0007744|PDB:4QKN, ECO:0007744|PDB:4ZS2
ChainResidueDetails
AARG322

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS216

229380

PDB entries from 2024-12-25

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