4IBV
Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation S240R in sequence-specific complex with DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006915 | biological_process | apoptotic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 301 |
| Chain | Residue |
| A | PRO177 |
| A | HIS178 |
| A | ARG181 |
| A | CYS182 |
| A | GLY244 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 302 |
| Chain | Residue |
| A | MET169 |
| A | THR170 |
| A | GLU171 |
| A | GLU198 |
| A | HOH482 |
| A | THR140 |
| A | SER166 |
| A | GLN167 |
| A | HIS168 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 303 |
| Chain | Residue |
| A | ASN131 |
| A | PRO152 |
| A | ASP259 |
| A | SER260 |
| A | SER261 |
| A | HOH405 |
| A | HOH484 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 304 |
| Chain | Residue |
| A | GLY154 |
| A | THR155 |
| A | ARG156 |
| A | PRO219 |
| A | EDO305 |
| A | EDO306 |
| A | HOH426 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 305 |
| Chain | Residue |
| A | LYS101 |
| A | THR102 |
| A | GLY154 |
| A | SER260 |
| A | EDO304 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 306 |
| Chain | Residue |
| A | PRO151 |
| A | PRO152 |
| A | PRO153 |
| A | THR155 |
| A | TYR220 |
| A | PRO222 |
| A | EDO304 |
| A | HOH498 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 307 |
| Chain | Residue |
| A | GLU180 |
| A | ARG181 |
| A | SER183 |
| A | PRO191 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 308 |
| Chain | Residue |
| A | CYS176 |
| A | HIS179 |
| A | CYS238 |
| A | CYS242 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 190 |
| Details | DNA_BIND: DNA_BIND => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130 |
| Chain | Residue | Details |
| A | THR102-LYS292 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130 |
| Chain | Residue | Details |
| A | CYS176 | |
| A | HIS179 | |
| A | CYS238 | |
| A | CYS242 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Interaction with DNA => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130 |
| Chain | Residue | Details |
| A | LYS120 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:23431171 |
| Chain | Residue | Details |
| A | LYS120 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462 |
| Chain | Residue | Details |
| A | SER183 | |
| A | SER269 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462 |
| Chain | Residue | Details |
| A | THR284 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19536131 |
| Chain | Residue | Details |
| A | LYS292 | |
| A | LYS291 |
