4I9N
Crystal structure of rabbit LDHA in complex with AP28161 and AP28122
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0006090 | biological_process | pyruvate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0006090 | biological_process | pyruvate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006089 | biological_process | lactate metabolic process |
| C | 0006090 | biological_process | pyruvate metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006089 | biological_process | lactate metabolic process |
| D | 0006090 | biological_process | pyruvate metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006089 | biological_process | lactate metabolic process |
| E | 0006090 | biological_process | pyruvate metabolic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| E | 0019752 | biological_process | carboxylic acid metabolic process |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006089 | biological_process | lactate metabolic process |
| F | 0006090 | biological_process | pyruvate metabolic process |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| F | 0019752 | biological_process | carboxylic acid metabolic process |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006089 | biological_process | lactate metabolic process |
| G | 0006090 | biological_process | pyruvate metabolic process |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| G | 0019752 | biological_process | carboxylic acid metabolic process |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006089 | biological_process | lactate metabolic process |
| H | 0006090 | biological_process | pyruvate metabolic process |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| H | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 1E6 A 401 |
| Chain | Residue |
| A | GLY26 |
| A | ILE119 |
| A | 1E5402 |
| A | HOH517 |
| A | GLY28 |
| A | ASP51 |
| A | VAL52 |
| A | THR94 |
| A | ALA95 |
| A | GLY96 |
| A | ILE115 |
| A | PHE118 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 1E5 A 402 |
| Chain | Residue |
| A | GLY28 |
| A | ALA29 |
| A | VAL30 |
| A | THR94 |
| A | VAL135 |
| A | SER136 |
| A | ASN137 |
| A | ARG168 |
| A | ALA237 |
| A | THR247 |
| A | 1E6401 |
| A | HOH509 |
| A | HOH518 |
| A | HOH546 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 1E6 B 401 |
| Chain | Residue |
| B | GLY26 |
| B | GLY28 |
| B | ASP51 |
| B | VAL52 |
| B | THR94 |
| B | ALA95 |
| B | GLY96 |
| B | ARG111 |
| B | ILE115 |
| B | PHE118 |
| B | ILE119 |
| B | 1E5402 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 1E5 B 402 |
| Chain | Residue |
| B | GLY28 |
| B | ALA29 |
| B | VAL30 |
| B | THR94 |
| B | VAL135 |
| B | SER136 |
| B | ASN137 |
| B | LEU164 |
| B | ARG168 |
| B | ALA237 |
| B | THR247 |
| B | 1E6401 |
| B | HOH520 |
| B | HOH529 |
| B | HOH532 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 1E6 C 401 |
| Chain | Residue |
| C | GLY26 |
| C | GLY28 |
| C | ASP51 |
| C | VAL52 |
| C | THR94 |
| C | ALA95 |
| C | GLY96 |
| C | ARG111 |
| C | ILE115 |
| C | PHE118 |
| C | ILE119 |
| C | 1E5402 |
| C | HOH534 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 1E5 C 402 |
| Chain | Residue |
| C | GLY28 |
| C | ALA29 |
| C | VAL30 |
| C | THR94 |
| C | VAL135 |
| C | SER136 |
| C | ASN137 |
| C | ARG168 |
| C | ALA237 |
| C | THR247 |
| C | 1E6401 |
| C | HOH510 |
| C | HOH512 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 1E6 D 401 |
| Chain | Residue |
| D | GLY28 |
| D | ASP51 |
| D | VAL52 |
| D | THR94 |
| D | ALA95 |
| D | GLY96 |
| D | ARG111 |
| D | ASN114 |
| D | ILE115 |
| D | PHE118 |
| D | ILE119 |
| D | 1E5402 |
| D | HOH535 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 1E5 D 402 |
| Chain | Residue |
| D | LEU164 |
| D | ARG168 |
| D | ALA237 |
| D | THR247 |
| D | 1E6401 |
| D | HOH510 |
| D | HOH519 |
| D | GLY28 |
| D | ALA29 |
| D | VAL30 |
| D | THR94 |
| D | VAL135 |
| D | SER136 |
| D | ASN137 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 1E6 E 401 |
| Chain | Residue |
| E | GLY26 |
| E | GLY28 |
| E | ASP51 |
| E | VAL52 |
| E | THR94 |
| E | ALA95 |
| E | GLY96 |
| E | ARG98 |
| E | ARG111 |
| E | ASN114 |
| E | ILE115 |
| E | PHE118 |
| E | ILE119 |
| E | 1E5402 |
| site_id | BC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 1E5 E 402 |
| Chain | Residue |
| E | GLY28 |
| E | ALA29 |
| E | VAL30 |
| E | THR94 |
| E | VAL135 |
| E | SER136 |
| E | ASN137 |
| E | ARG168 |
| E | ALA237 |
| E | THR247 |
| E | 1E6401 |
| E | HOH506 |
| E | HOH515 |
| site_id | BC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 1E6 F 401 |
| Chain | Residue |
| F | GLY26 |
| F | VAL27 |
| F | GLY28 |
| F | ASP51 |
| F | VAL52 |
| F | THR94 |
| F | ALA95 |
| F | GLY96 |
| F | ARG98 |
| F | ARG111 |
| F | ASN114 |
| F | ILE115 |
| F | PHE118 |
| F | 1E5402 |
| F | HOH508 |
| site_id | BC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 1E5 F 402 |
| Chain | Residue |
| F | GLY28 |
| F | ALA29 |
| F | VAL30 |
| F | THR94 |
| F | VAL135 |
| F | SER136 |
| F | ASN137 |
| F | ARG168 |
| F | ALA237 |
| F | THR247 |
| F | 1E6401 |
| F | HOH509 |
| site_id | BC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 1E6 G 401 |
| Chain | Residue |
| G | VAL25 |
| G | GLY26 |
| G | GLY28 |
| G | ASP51 |
| G | VAL52 |
| G | THR94 |
| G | ALA95 |
| G | GLY96 |
| G | ARG111 |
| G | ILE115 |
| G | PHE118 |
| G | ILE119 |
| G | 1E5402 |
| G | HOH522 |
| site_id | BC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 1E5 G 402 |
| Chain | Residue |
| G | GLY28 |
| G | VAL30 |
| G | THR94 |
| G | VAL135 |
| G | SER136 |
| G | ASN137 |
| G | LEU164 |
| G | ARG168 |
| G | ALA237 |
| G | THR247 |
| G | 1E6401 |
| G | HOH511 |
| G | HOH539 |
| site_id | BC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 1E6 H 401 |
| Chain | Residue |
| H | GLY26 |
| H | GLY28 |
| H | ASP51 |
| H | VAL52 |
| H | THR94 |
| H | ALA95 |
| H | GLY96 |
| H | ARG111 |
| H | ILE115 |
| H | PHE118 |
| H | ILE119 |
| H | 1E5402 |
| site_id | BC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 1E5 H 402 |
| Chain | Residue |
| H | GLY28 |
| H | ALA29 |
| H | VAL30 |
| H | THR94 |
| H | VAL135 |
| H | SER136 |
| H | ASN137 |
| H | ARG168 |
| H | ALA237 |
| H | THR247 |
| H | 1E6401 |
| H | HOH513 |
| H | HOH527 |
Functional Information from PROSITE/UniProt
| site_id | PS00064 |
| Number of Residues | 7 |
| Details | L_LDH L-lactate dehydrogenase active site. LGEHGDS |
| Chain | Residue | Details |
| A | LEU189-SER195 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:19715328 |
| Chain | Residue | Details |
| H | HIS192 | |
| B | HIS192 | |
| C | HIS192 | |
| D | HIS192 | |
| E | HIS192 | |
| F | HIS192 | |
| G | HIS192 | |
| A | HIS192 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 48 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | ASN137 | |
| B | ARG168 | |
| B | THR247 | |
| C | GLY28 | |
| C | ARG98 | |
| C | ARG105 | |
| C | ASN137 | |
| C | ARG168 | |
| C | THR247 | |
| D | GLY28 | |
| D | ARG98 | |
| D | ARG105 | |
| D | ASN137 | |
| D | ARG168 | |
| D | THR247 | |
| E | GLY28 | |
| E | ARG98 | |
| E | ARG105 | |
| E | ASN137 | |
| E | ARG168 | |
| E | THR247 | |
| F | GLY28 | |
| F | ARG98 | |
| F | ARG105 | |
| F | ASN137 | |
| F | ARG168 | |
| F | THR247 | |
| G | GLY28 | |
| G | ARG98 | |
| G | ARG105 | |
| G | ASN137 | |
| G | ARG168 | |
| G | THR247 | |
| H | GLY28 | |
| H | ARG98 | |
| H | ARG105 | |
| H | ASN137 | |
| H | ARG168 | |
| H | THR247 | |
| B | ARG104 | |
| A | ARG98 | |
| A | ARG105 | |
| A | ASN137 | |
| A | ARG168 | |
| A | THR247 | |
| B | GLY28 | |
| B | ARG97 | |
| A | GLY28 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P00338 |
| Chain | Residue | Details |
| B | ALA1 | |
| C | ALA1 | |
| D | ALA1 | |
| E | ALA1 | |
| F | ALA1 | |
| G | ALA1 | |
| H | ALA1 | |
| A | ALA1 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P06151 |
| Chain | Residue | Details |
| D | LYS4 | |
| D | LYS117 | |
| D | LYS317 | |
| E | LYS4 | |
| E | LYS117 | |
| E | LYS317 | |
| F | LYS4 | |
| F | LYS117 | |
| F | LYS317 | |
| G | LYS4 | |
| G | LYS117 | |
| G | LYS317 | |
| H | LYS4 | |
| H | LYS117 | |
| H | LYS317 | |
| B | LYS4 | |
| B | LYS117 | |
| B | LYS317 | |
| C | LYS4 | |
| C | LYS117 | |
| C | LYS317 | |
| A | LYS4 | |
| A | LYS117 | |
| A | LYS317 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P00338 |
| Chain | Residue | Details |
| D | LYS13 | |
| D | LYS80 | |
| D | LYS125 | |
| E | LYS13 | |
| E | LYS80 | |
| E | LYS125 | |
| F | LYS13 | |
| F | LYS80 | |
| F | LYS125 | |
| G | LYS13 | |
| G | LYS80 | |
| G | LYS125 | |
| H | LYS13 | |
| H | LYS80 | |
| H | LYS125 | |
| C | LYS125 | |
| A | LYS80 | |
| A | LYS125 | |
| B | LYS13 | |
| B | LYS80 | |
| B | LYS125 | |
| C | LYS13 | |
| C | LYS80 | |
| A | LYS13 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P00338 |
| Chain | Residue | Details |
| B | LYS56 | |
| C | LYS56 | |
| D | LYS56 | |
| E | LYS56 | |
| F | LYS56 | |
| G | LYS56 | |
| H | LYS56 | |
| A | LYS56 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P06151 |
| Chain | Residue | Details |
| G | LYS223 | |
| G | LYS231 | |
| G | LYS242 | |
| D | LYS223 | |
| D | LYS231 | |
| D | LYS242 | |
| E | LYS223 | |
| E | LYS231 | |
| E | LYS242 | |
| F | LYS223 | |
| F | LYS231 | |
| F | LYS242 | |
| A | LYS231 | |
| H | LYS223 | |
| H | LYS231 | |
| H | LYS242 | |
| A | LYS242 | |
| B | LYS223 | |
| B | LYS231 | |
| B | LYS242 | |
| C | LYS223 | |
| C | LYS231 | |
| C | LYS242 | |
| A | LYS223 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P06151 |
| Chain | Residue | Details |
| B | TYR238 | |
| C | TYR238 | |
| D | TYR238 | |
| E | TYR238 | |
| F | TYR238 | |
| G | TYR238 | |
| H | TYR238 | |
| A | TYR238 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 16 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P04642 |
| Chain | Residue | Details |
| E | THR321 | |
| F | THR308 | |
| F | THR321 | |
| G | THR308 | |
| G | THR321 | |
| H | THR308 | |
| H | THR321 | |
| D | THR308 | |
| B | THR321 | |
| C | THR308 | |
| C | THR321 | |
| D | THR321 | |
| E | THR308 | |
| A | THR308 | |
| A | THR321 | |
| B | THR308 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P00338 |
| Chain | Residue | Details |
| H | SER309 | |
| B | SER309 | |
| C | SER309 | |
| D | SER309 | |
| E | SER309 | |
| F | SER309 | |
| G | SER309 | |
| A | SER309 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 16 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P00338 |
| Chain | Residue | Details |
| F | LYS56 | |
| G | LYS56 | |
| H | LYS56 | |
| B | LYS56 | |
| C | LYS56 | |
| D | LYS56 | |
| E | LYS56 | |
| A | LYS56 |
