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4I8J

Bovine trypsin at 0.87 A resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0004175molecular_functionendopeptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006508biological_processproteolysis
A0007586biological_processdigestion
A0008236molecular_functionserine-type peptidase activity
A0046872molecular_functionmetal ion binding
A0097180cellular_componentserine protease inhibitor complex
A0097655molecular_functionserpin family protein binding
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 301
ChainResidue
AGLU70
AASN72
AVAL75
AGLU80
AHOH401
AHOH402

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE BEN A 302
ChainResidue
AGLN192
ASER195
ASER214
ATRP215
AGLY216
AGLY219
ACYS220
AGLY226
ASO4303
AHOH429
AHOH514
AASP189
ASER190
ACYS191

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 303
ChainResidue
AHIS57
AGLN192
AGLY193
ASER195
ABEN302
AHOH467
AHOH722
AHOH767

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 304
ChainResidue
ALYS169
APRO173
AGLY174
AHOH412
AHOH529
AHOH549
AHOH575
AHOH809

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 305
ChainResidue
AGLU80
AGLN81
APHE82
AHOH497
AHOH647
AHOH720

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC
ChainResidueDetails
AVAL53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV
ChainResidueDetails
AASP189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AHIS57
AASP102
ASER195

site_idSWS_FT_FI2
Number of Residues7
DetailsBINDING:
ChainResidueDetails
AGLU70
AASN72
AVAL75
AGLU80
AASP189
AGLN192
ASER195

226707

PDB entries from 2024-10-30

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