4I6G
a vertebrate cryptochrome with FAD
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE FAD A 900 |
| Chain | Residue |
| A | LEU269 |
| A | PHE399 |
| A | LEU403 |
| A | ASP405 |
| A | ALA406 |
| A | ASP407 |
| A | VAL410 |
| A | ASN411 |
| A | SER414 |
| A | TRP415 |
| A | LEU418 |
| A | SER270 |
| A | HOH1029 |
| A | HOH1033 |
| A | HOH1068 |
| A | HOH1100 |
| A | LEU273 |
| A | GLN307 |
| A | TRP310 |
| A | ARG311 |
| A | HIS373 |
| A | ARG376 |
| A | HIS377 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE FAD B 900 |
| Chain | Residue |
| B | LEU269 |
| B | SER270 |
| B | LEU273 |
| B | GLN307 |
| B | TRP310 |
| B | ARG311 |
| B | TRP370 |
| B | HIS373 |
| B | ARG376 |
| B | LEU403 |
| B | ASP405 |
| B | ALA406 |
| B | ASP407 |
| B | VAL410 |
| B | ASN411 |
| B | SER414 |
| B | LEU418 |
| B | HOH1018 |
| B | HOH1024 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 258 |
| Details | Domain: {"description":"Photolyase/cryptochrome alpha/beta"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 198 |
| Details | Region: {"description":"Required for inhibition of CLOCK-BMAL1-mediated transcription","evidences":[{"source":"UniProtKB","id":"P97784","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23503662","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P97784","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P97784","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by MAPK","evidences":[{"source":"PubMed","id":"11875063","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15298678","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P97784","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23452856","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
