4I6A
3-hydroxy-3-methylglutaryl (HMG) Coenzyme A reductase from Pseudomonas mevalonii complexed with HMG-CoA
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
A | 0015936 | biological_process | coenzyme A metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0140643 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADH) activity |
B | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
B | 0015936 | biological_process | coenzyme A metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0140643 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADH) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE HMG A 501 |
Chain | Residue |
A | ARG11 |
A | GLN364 |
A | ALA368 |
A | ALA371 |
A | LEU372 |
A | ILE377 |
A | HOH603 |
A | HOH657 |
A | HOH678 |
A | HOH728 |
A | HOH749 |
A | SER85 |
A | HOH751 |
A | HOH761 |
B | GLU552 |
B | ASN553 |
B | ILE713 |
B | HOH1173 |
A | ALA88 |
A | TYR92 |
A | LYS95 |
A | ARG261 |
A | THR264 |
A | GLY268 |
A | ASN271 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 B 1001 |
Chain | Residue |
B | ARG761 |
B | THR764 |
B | HIS765 |
B | ALA868 |
B | LEU872 |
B | HOH1113 |
Functional Information from PROSITE/UniProt
site_id | PS00066 |
Number of Residues | 15 |
Details | HMG_COA_REDUCTASE_1 Hydroxymethylglutaryl-coenzyme A reductases signature 1. HlIVdVRDaMGaNtV |
Chain | Residue | Details |
A | HIS176-VAL190 |
site_id | PS00318 |
Number of Residues | 8 |
Details | HMG_COA_REDUCTASE_2 Hydroxymethylglutaryl-coenzyme A reductases signature 2. VGlVGGAT |
Chain | Residue | Details |
A | VAL325-THR332 |
site_id | PS01192 |
Number of Residues | 14 |
Details | HMG_COA_REDUCTASE_3 Hydroxymethylglutaryl-coenzyme A reductases signature 3. ALaTegIqRGHMaL |
Chain | Residue | Details |
A | ALA371-LEU384 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: Charge relay system |
Chain | Residue | Details |
A | GLU83 | |
A | LYS267 | |
A | ASP283 | |
B | GLU583 | |
B | LYS767 | |
B | ASP783 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU10003, ECO:0000269|PubMed:1634543 |
Chain | Residue | Details |
A | HIS381 | |
B | HIS881 |