4I4Z
Synechocystis sp. PCC 6803 1,4-dihydroxy-2-naphthoyl-coenzyme A synthase (MenB) in complex with salicylyl-CoA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| A | 0009234 | biological_process | menaquinone biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0042372 | biological_process | phylloquinone biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| B | 0009234 | biological_process | menaquinone biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0042372 | biological_process | phylloquinone biosynthetic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| C | 0009234 | biological_process | menaquinone biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0042372 | biological_process | phylloquinone biosynthetic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| D | 0009234 | biological_process | menaquinone biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0042372 | biological_process | phylloquinone biosynthetic process |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| E | 0009234 | biological_process | menaquinone biosynthetic process |
| E | 0016829 | molecular_function | lyase activity |
| E | 0042372 | biological_process | phylloquinone biosynthetic process |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| F | 0009234 | biological_process | menaquinone biosynthetic process |
| F | 0016829 | molecular_function | lyase activity |
| F | 0042372 | biological_process | phylloquinone biosynthetic process |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| G | 0009234 | biological_process | menaquinone biosynthetic process |
| G | 0016829 | molecular_function | lyase activity |
| G | 0042372 | biological_process | phylloquinone biosynthetic process |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| H | 0009234 | biological_process | menaquinone biosynthetic process |
| H | 0016829 | molecular_function | lyase activity |
| H | 0042372 | biological_process | phylloquinone biosynthetic process |
| I | 0003824 | molecular_function | catalytic activity |
| I | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| I | 0009234 | biological_process | menaquinone biosynthetic process |
| I | 0016829 | molecular_function | lyase activity |
| I | 0042372 | biological_process | phylloquinone biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 2NE A 301 |
| Chain | Residue |
| A | HIS29 |
| A | VAL98 |
| A | TYR119 |
| A | GLY123 |
| A | THR145 |
| A | VAL149 |
| A | BCT302 |
| A | HOH413 |
| A | HOH430 |
| A | HOH509 |
| C | GLN91 |
| A | LYS30 |
| C | GLY92 |
| F | PHE260 |
| F | LYS263 |
| A | ARG31 |
| A | SER75 |
| A | GLY76 |
| A | GLY77 |
| A | ASP78 |
| A | GLN79 |
| A | TYR87 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BCT A 302 |
| Chain | Residue |
| A | GLY122 |
| A | GLY123 |
| A | GLN144 |
| A | THR145 |
| A | GLY146 |
| A | TRP174 |
| A | 2NE301 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 2NE B 301 |
| Chain | Residue |
| B | HIS29 |
| B | LYS30 |
| B | ARG31 |
| B | ALA33 |
| B | SER75 |
| B | GLY76 |
| B | GLY77 |
| B | ASP78 |
| B | GLN79 |
| B | TYR87 |
| B | VAL98 |
| B | TYR119 |
| B | GLY123 |
| B | THR145 |
| B | VAL149 |
| B | SER151 |
| B | BCT302 |
| B | HOH455 |
| D | PHE260 |
| D | LYS263 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BCT B 302 |
| Chain | Residue |
| B | GLY122 |
| B | GLY123 |
| B | GLN144 |
| B | THR145 |
| B | GLY146 |
| B | TRP174 |
| B | 2NE301 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 2NE C 301 |
| Chain | Residue |
| C | HIS29 |
| C | LYS30 |
| C | ARG31 |
| C | ALA33 |
| C | SER75 |
| C | GLY76 |
| C | GLY77 |
| C | ASP78 |
| C | GLN79 |
| C | TYR87 |
| C | VAL98 |
| C | TYR119 |
| C | GLY123 |
| C | THR145 |
| C | VAL149 |
| C | BCT302 |
| C | HOH409 |
| C | HOH499 |
| C | HOH526 |
| E | PHE260 |
| E | LYS263 |
| E | HOH496 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BCT C 302 |
| Chain | Residue |
| C | GLY122 |
| C | GLY123 |
| C | GLN144 |
| C | THR145 |
| C | GLY146 |
| C | TRP174 |
| C | 2NE301 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MLI C 303 |
| Chain | Residue |
| A | ARG187 |
| C | ILE164 |
| D | ILE164 |
| site_id | AC8 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 2NE D 301 |
| Chain | Residue |
| D | TYR87 |
| D | VAL98 |
| D | TYR119 |
| D | GLY123 |
| D | THR145 |
| D | VAL149 |
| D | BCT302 |
| D | HOH440 |
| D | HOH450 |
| B | PHE260 |
| B | LYS263 |
| D | HIS29 |
| D | LYS30 |
| D | ARG31 |
| D | ALA33 |
| D | SER75 |
| D | GLY76 |
| D | GLY77 |
| D | ASP78 |
| D | GLN79 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BCT D 302 |
| Chain | Residue |
| D | GLY122 |
| D | GLY123 |
| D | GLN144 |
| D | THR145 |
| D | GLY146 |
| D | TRP174 |
| D | 2NE301 |
| site_id | BC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 2NE E 301 |
| Chain | Residue |
| C | PHE260 |
| C | LYS263 |
| E | HIS29 |
| E | LYS30 |
| E | ARG31 |
| E | ALA33 |
| E | SER75 |
| E | GLY76 |
| E | GLY77 |
| E | ASP78 |
| E | GLN79 |
| E | TYR87 |
| E | VAL98 |
| E | TYR119 |
| E | GLY123 |
| E | THR145 |
| E | VAL149 |
| E | SER151 |
| E | BCT302 |
| E | HOH414 |
| E | HOH453 |
| E | HOH454 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BCT E 302 |
| Chain | Residue |
| E | GLY122 |
| E | GLY123 |
| E | GLN144 |
| E | THR145 |
| E | GLY146 |
| E | TRP174 |
| E | 2NE301 |
| site_id | BC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 2NE F 301 |
| Chain | Residue |
| A | PHE260 |
| A | LYS263 |
| F | HIS29 |
| F | LYS30 |
| F | ARG31 |
| F | ALA33 |
| F | SER75 |
| F | GLY76 |
| F | GLY77 |
| F | ASP78 |
| F | GLN79 |
| F | TYR87 |
| F | VAL98 |
| F | TYR119 |
| F | GLY123 |
| F | THR145 |
| F | VAL149 |
| F | SER151 |
| F | PHE152 |
| F | BCT302 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BCT F 302 |
| Chain | Residue |
| F | GLY122 |
| F | GLY123 |
| F | GLN144 |
| F | THR145 |
| F | GLY146 |
| F | TRP174 |
| F | 2NE301 |
| site_id | BC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 2NE G 301 |
| Chain | Residue |
| G | HIS29 |
| G | LYS30 |
| G | ARG31 |
| G | ALA33 |
| G | SER75 |
| G | GLY76 |
| G | GLY77 |
| G | ASP78 |
| G | GLN79 |
| G | TYR87 |
| G | TYR119 |
| G | GLY123 |
| G | THR145 |
| G | VAL149 |
| G | BCT302 |
| G | HOH451 |
| I | TYR248 |
| I | LYS263 |
| site_id | BC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BCT G 302 |
| Chain | Residue |
| G | GLY122 |
| G | GLY123 |
| G | GLN144 |
| G | THR145 |
| G | GLY146 |
| G | SER151 |
| G | TRP174 |
| G | 2NE301 |
| site_id | BC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 2NE H 301 |
| Chain | Residue |
| H | ARG31 |
| H | SER75 |
| H | GLY77 |
| H | ASP78 |
| H | GLN79 |
| H | TYR87 |
| H | TYR119 |
| H | GLY122 |
| H | GLY123 |
| H | THR145 |
| H | VAL149 |
| H | SER151 |
| H | PHE152 |
| H | GLN179 |
| H | PHE260 |
| H | LYS263 |
| H | BCT302 |
| site_id | BC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BCT H 302 |
| Chain | Residue |
| H | GLY122 |
| H | GLY123 |
| H | GLN144 |
| H | THR145 |
| H | GLY146 |
| H | PHE152 |
| H | TRP174 |
| H | 2NE301 |
| site_id | BC9 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE 2NE I 301 |
| Chain | Residue |
| G | PHE260 |
| G | LYS263 |
| I | HIS29 |
| I | LYS30 |
| I | ARG31 |
| I | ALA33 |
| I | SER75 |
| I | GLY76 |
| I | GLY77 |
| I | ASP78 |
| I | GLN79 |
| I | TYR87 |
| I | VAL98 |
| I | TYR119 |
| I | GLY123 |
| I | THR145 |
| I | VAL149 |
| I | SER151 |
| I | GLN179 |
| I | BCT302 |
| I | HOH417 |
| I | HOH432 |
| I | HOH445 |
| I | HOH470 |
| site_id | CC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BCT I 302 |
| Chain | Residue |
| I | GLY122 |
| I | GLY123 |
| I | GLN144 |
| I | THR145 |
| I | GLY146 |
| I | PHE152 |
| I | TRP174 |
| I | 2NE301 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MLI I 303 |
| Chain | Residue |
| H | ILE164 |
| H | ARG187 |
| I | ILE164 |
| I | ARG187 |
| I | MET188 |
Functional Information from PROSITE/UniProt
| site_id | PS00166 |
| Number of Residues | 21 |
| Details | ENOYL_COA_HYDRATASE Enoyl-CoA hydratase/isomerase signature. IAlVAGyaiGGGhvlhLvCDL |
| Chain | Residue | Details |
| A | ILE113-LEU133 |
