Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4I4Z

Synechocystis sp. PCC 6803 1,4-dihydroxy-2-naphthoyl-coenzyme A synthase (MenB) in complex with salicylyl-CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005829	cellular_component	cytosol
A	0008935	molecular_function	1,4-dihydroxy-2-naphthoyl-CoA synthase activity
A	0009234	biological_process	menaquinone biosynthetic process
A	0016829	molecular_function	lyase activity
A	0042372	biological_process	phylloquinone biosynthetic process
B	0003824	molecular_function	catalytic activity
B	0005829	cellular_component	cytosol
B	0008935	molecular_function	1,4-dihydroxy-2-naphthoyl-CoA synthase activity
B	0009234	biological_process	menaquinone biosynthetic process
B	0016829	molecular_function	lyase activity
B	0042372	biological_process	phylloquinone biosynthetic process
C	0003824	molecular_function	catalytic activity
C	0005829	cellular_component	cytosol
C	0008935	molecular_function	1,4-dihydroxy-2-naphthoyl-CoA synthase activity
C	0009234	biological_process	menaquinone biosynthetic process
C	0016829	molecular_function	lyase activity
C	0042372	biological_process	phylloquinone biosynthetic process
D	0003824	molecular_function	catalytic activity
D	0005829	cellular_component	cytosol
D	0008935	molecular_function	1,4-dihydroxy-2-naphthoyl-CoA synthase activity
D	0009234	biological_process	menaquinone biosynthetic process
D	0016829	molecular_function	lyase activity
D	0042372	biological_process	phylloquinone biosynthetic process
E	0003824	molecular_function	catalytic activity
E	0005829	cellular_component	cytosol
E	0008935	molecular_function	1,4-dihydroxy-2-naphthoyl-CoA synthase activity
E	0009234	biological_process	menaquinone biosynthetic process
E	0016829	molecular_function	lyase activity
E	0042372	biological_process	phylloquinone biosynthetic process
F	0003824	molecular_function	catalytic activity
F	0005829	cellular_component	cytosol
F	0008935	molecular_function	1,4-dihydroxy-2-naphthoyl-CoA synthase activity
F	0009234	biological_process	menaquinone biosynthetic process
F	0016829	molecular_function	lyase activity
F	0042372	biological_process	phylloquinone biosynthetic process
G	0003824	molecular_function	catalytic activity
G	0005829	cellular_component	cytosol
G	0008935	molecular_function	1,4-dihydroxy-2-naphthoyl-CoA synthase activity
G	0009234	biological_process	menaquinone biosynthetic process
G	0016829	molecular_function	lyase activity
G	0042372	biological_process	phylloquinone biosynthetic process
H	0003824	molecular_function	catalytic activity
H	0005829	cellular_component	cytosol
H	0008935	molecular_function	1,4-dihydroxy-2-naphthoyl-CoA synthase activity
H	0009234	biological_process	menaquinone biosynthetic process
H	0016829	molecular_function	lyase activity
H	0042372	biological_process	phylloquinone biosynthetic process
I	0003824	molecular_function	catalytic activity
I	0005829	cellular_component	cytosol
I	0008935	molecular_function	1,4-dihydroxy-2-naphthoyl-CoA synthase activity
I	0009234	biological_process	menaquinone biosynthetic process
I	0016829	molecular_function	lyase activity
I	0042372	biological_process	phylloquinone biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE 2NE A 301

Chain	Residue
A	HIS29
A	VAL98
A	TYR119
A	GLY123
A	THR145
A	VAL149
A	BCT302
A	HOH413
A	HOH430
A	HOH509
C	GLN91
A	LYS30
C	GLY92
F	PHE260
F	LYS263
A	ARG31
A	SER75
A	GLY76
A	GLY77
A	ASP78
A	GLN79
A	TYR87

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BCT A 302

Chain	Residue
A	GLY122
A	GLY123
A	GLN144
A	THR145
A	GLY146
A	TRP174
A	2NE301

site_id	AC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 2NE B 301

Chain	Residue
B	HIS29
B	LYS30
B	ARG31
B	ALA33
B	SER75
B	GLY76
B	GLY77
B	ASP78
B	GLN79
B	TYR87
B	VAL98
B	TYR119
B	GLY123
B	THR145
B	VAL149
B	SER151
B	BCT302
B	HOH455
D	PHE260
D	LYS263

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BCT B 302

Chain	Residue
B	GLY122
B	GLY123
B	GLN144
B	THR145
B	GLY146
B	TRP174
B	2NE301

site_id	AC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE 2NE C 301

Chain	Residue
C	HIS29
C	LYS30
C	ARG31
C	ALA33
C	SER75
C	GLY76
C	GLY77
C	ASP78
C	GLN79
C	TYR87
C	VAL98
C	TYR119
C	GLY123
C	THR145
C	VAL149
C	BCT302
C	HOH409
C	HOH499
C	HOH526
E	PHE260
E	LYS263
E	HOH496

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BCT C 302

Chain	Residue
C	GLY122
C	GLY123
C	GLN144
C	THR145
C	GLY146
C	TRP174
C	2NE301

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MLI C 303

Chain	Residue
A	ARG187
C	ILE164
D	ILE164

site_id	AC8
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 2NE D 301

Chain	Residue
D	TYR87
D	VAL98
D	TYR119
D	GLY123
D	THR145
D	VAL149
D	BCT302
D	HOH440
D	HOH450
B	PHE260
B	LYS263
D	HIS29
D	LYS30
D	ARG31
D	ALA33
D	SER75
D	GLY76
D	GLY77
D	ASP78
D	GLN79

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BCT D 302

Chain	Residue
D	GLY122
D	GLY123
D	GLN144
D	THR145
D	GLY146
D	TRP174
D	2NE301

site_id	BC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE 2NE E 301

Chain	Residue
C	PHE260
C	LYS263
E	HIS29
E	LYS30
E	ARG31
E	ALA33
E	SER75
E	GLY76
E	GLY77
E	ASP78
E	GLN79
E	TYR87
E	VAL98
E	TYR119
E	GLY123
E	THR145
E	VAL149
E	SER151
E	BCT302
E	HOH414
E	HOH453
E	HOH454

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BCT E 302

Chain	Residue
E	GLY122
E	GLY123
E	GLN144
E	THR145
E	GLY146
E	TRP174
E	2NE301

site_id	BC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 2NE F 301

Chain	Residue
A	PHE260
A	LYS263
F	HIS29
F	LYS30
F	ARG31
F	ALA33
F	SER75
F	GLY76
F	GLY77
F	ASP78
F	GLN79
F	TYR87
F	VAL98
F	TYR119
F	GLY123
F	THR145
F	VAL149
F	SER151
F	PHE152
F	BCT302

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BCT F 302

Chain	Residue
F	GLY122
F	GLY123
F	GLN144
F	THR145
F	GLY146
F	TRP174
F	2NE301

site_id	BC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 2NE G 301

Chain	Residue
G	HIS29
G	LYS30
G	ARG31
G	ALA33
G	SER75
G	GLY76
G	GLY77
G	ASP78
G	GLN79
G	TYR87
G	TYR119
G	GLY123
G	THR145
G	VAL149
G	BCT302
G	HOH451
I	TYR248
I	LYS263

site_id	BC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BCT G 302

Chain	Residue
G	GLY122
G	GLY123
G	GLN144
G	THR145
G	GLY146
G	SER151
G	TRP174
G	2NE301

site_id	BC7
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 2NE H 301

Chain	Residue
H	ARG31
H	SER75
H	GLY77
H	ASP78
H	GLN79
H	TYR87
H	TYR119
H	GLY122
H	GLY123
H	THR145
H	VAL149
H	SER151
H	PHE152
H	GLN179
H	PHE260
H	LYS263
H	BCT302

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BCT H 302

Chain	Residue
H	GLY122
H	GLY123
H	GLN144
H	THR145
H	GLY146
H	PHE152
H	TRP174
H	2NE301

site_id	BC9
Number of Residues	24
Details	BINDING SITE FOR RESIDUE 2NE I 301

Chain	Residue
G	PHE260
G	LYS263
I	HIS29
I	LYS30
I	ARG31
I	ALA33
I	SER75
I	GLY76
I	GLY77
I	ASP78
I	GLN79
I	TYR87
I	VAL98
I	TYR119
I	GLY123
I	THR145
I	VAL149
I	SER151
I	GLN179
I	BCT302
I	HOH417
I	HOH432
I	HOH445
I	HOH470

site_id	CC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BCT I 302

Chain	Residue
I	GLY122
I	GLY123
I	GLN144
I	THR145
I	GLY146
I	PHE152
I	TRP174
I	2NE301

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MLI I 303

Chain	Residue
H	ILE164
H	ARG187
I	ILE164
I	ARG187
I	MET188

Functional Information from PROSITE/UniProt

site_id	PS00166
Number of Residues	21
Details	ENOYL_COA_HYDRATASE Enoyl-CoA hydratase/isomerase signature. IAlVAGyaiGGGhvlhLvCDL

Chain	Residue	Details
A	ILE113-LEU133

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)