4I33
Crystal structure of HCV NS3/4A R155K protease complexed with compound 4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0019087 | biological_process | symbiont-mediated transformation of host cell |
| B | 0006508 | biological_process | proteolysis |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0019087 | biological_process | symbiont-mediated transformation of host cell |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 201 |
| Chain | Residue |
| A | ALA5 |
| A | ALA111 |
| A | HOH303 |
| A | HOH327 |
| A | HOH334 |
| A | HOH350 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 1BV A 202 |
| Chain | Residue |
| A | TYR56 |
| A | HIS57 |
| A | GLY58 |
| A | VAL78 |
| A | ASP79 |
| A | ASP81 |
| A | LEU135 |
| A | LYS136 |
| A | GLY137 |
| A | SER138 |
| A | SER139 |
| A | PHE154 |
| A | LYS155 |
| A | ALA156 |
| A | ALA157 |
| A | HOH324 |
| A | HOH355 |
| A | GLN41 |
| A | SER42 |
| A | PHE43 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 201 |
| Chain | Residue |
| B | ALA5 |
| B | ALA111 |
| B | HOH320 |
| B | HOH333 |
| B | HOH338 |
| B | HOH343 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 1BV B 202 |
| Chain | Residue |
| B | GLN41 |
| B | SER42 |
| B | PHE43 |
| B | TYR56 |
| B | HIS57 |
| B | VAL78 |
| B | ASP79 |
| B | ASP81 |
| B | VAL132 |
| B | LEU135 |
| B | LYS136 |
| B | GLY137 |
| B | SER138 |
| B | SER139 |
| B | PHE154 |
| B | LYS155 |
| B | ALA156 |
| B | ALA157 |
| B | ASP168 |
| B | HOH330 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system; for serine protease NS3 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8389908","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"8392606","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9060645","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system; for serine protease NS3 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8389908","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"8392606","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system; for serine protease NS3 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9060645","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
