4I2E

Ternary complex of mouse TdT with ssDNA and AMPcPP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CO A 601

Chain	Residue
A	ASP343
A	ASP345
A	APC603
A	CO604
A	HOH971

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 602

Chain	Residue
C	DA4
C	HOH101
A	THR253
A	VAL255
A	VAL258
A	HOH978

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site_id	AC3
Number of Residues	25
Details	BINDING SITE FOR RESIDUE APC A 603

Chain	Residue
A	GLY332
A	GLY333
A	ARG336
A	GLY341
A	HIS342
A	ASP343
A	ASP345
A	PHE405
A	ASP434
A	GLY449
A	TRP450
A	GLY452
A	CO601
A	CO604
A	HOH906
A	HOH929
A	HOH971
A	HOH972
A	HOH979
A	HOH1031
A	HOH1050
A	HOH1060
A	HOH1087
A	HOH1096
C	DA4

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO A 604

Chain	Residue
A	ASP343
A	ASP345
A	ASP434
A	CO601
A	APC603
A	HOH972

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Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GGFrRGkmtGhDVDFLItsP

Chain	Residue	Details
A	GLY332-PRO351

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305, ECO:0007744|PDB:4I2B, ECO:0007744|PDB:4I2C, ECO:0007744|PDB:4I2D, ECO:0007744|PDB:4I2E

Chain	Residue	Details
A	GLY333
A	HIS342
A	GLY449

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305, ECO:0007744|PDB:1JMS, ECO:0007744|PDB:4I2B

Chain	Residue	Details
A	ASP343
A	ASP345
A	ASP434

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	SER134

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 632

Chain	Residue	Details
A	ASP343	metal ligand
A	ASP345	metal ligand
A	ASP434	metal ligand, proton acceptor, proton donor

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