4HZ3

MthK pore crystallized in presence of TBSb

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE K D 201

Chain	Residue
A	GLY61
A	TYR62
B	GLY61
B	TYR62
C	GLY61
C	TYR62
D	GLY61
D	TYR62
D	K202

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE K D 202

Chain	Residue
A	VAL60
A	GLY61
B	VAL60
B	GLY61
C	VAL60
C	GLY61
D	VAL60
D	GLY61
D	K201
D	K203

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE K D 203

Chain	Residue
A	THR59
A	VAL60
B	THR59
B	VAL60
C	THR59
C	VAL60
D	THR59
D	VAL60
D	K202
D	K204

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K D 204

Chain	Residue
A	THR59
B	THR59
C	THR59
D	THR59
D	K203

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HEZ D 205

Chain	Residue
D	HOH317

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HEZ D 206

Chain	Residue
D	ARG22

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HEZ D 207

Chain	Residue
D	TYR74

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HEZ C 201

Chain	Residue
C	HOH321
G	ALA29
G	ILE32

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HEZ C 202

Chain	Residue
C	ARG22
C	LEU26
G	ILE32

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE HEZ C 203

Chain	Residue
A	LEU50
C	TYR74
C	CYS77
C	VAL81

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HEZ A 201

Chain	Residue
A	ALA29
A	HOH324

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HEZ A 202

Chain	Residue
A	ARG22
A	LEU26
A	ALA29

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HEZ A 203

Chain	Residue
A	TYR74
A	VAL81

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HEZ B 201

Chain	Residue
B	HOH317
E	ALA29

---

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HEZ B 202

Chain	Residue
B	ARG22

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HEZ B 203

Chain	Residue
B	TYR74
B	VAL81
C	LEU50

---

site_id	BC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE K E 201

Chain	Residue
E	GLY61
E	TYR62
E	K202
F	GLY61
F	TYR62
G	GLY61
G	TYR62
H	GLY61
H	TYR62

---

site_id	BC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE K E 202

Chain	Residue
E	VAL60
E	GLY61
E	K201
E	K203
F	VAL60
F	GLY61
G	VAL60
G	GLY61
H	VAL60
H	GLY61

---

site_id	CC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE K E 203

Chain	Residue
E	THR59
E	VAL60
E	K202
E	K204
F	THR59
F	VAL60
G	THR59
G	VAL60
H	THR59
H	VAL60

---

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K E 204

Chain	Residue
E	THR59
E	K203
F	THR59
G	THR59
H	THR59

---

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE HEZ E 205

Chain	Residue
B	ILE32
B	TRP46
E	ARG22
E	LEU26

---

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HEZ E 206

Chain	Residue
E	CYS77
H	LEU50
E	TYR74

---

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HEZ F 201

Chain	Residue
F	ARG22
F	LEU26

---

site_id	CC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HEZ F 202

Chain	Residue
F	TYR74

---

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HEZ F 203

Chain	Residue
F	LEU50
H	TYR74
H	VAL81

---

site_id	CC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HEZ G 201

Chain	Residue
G	ARG22

---

site_id	CC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HEZ G 202

Chain	Residue
G	TYR74

---

site_id	DC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HEZ H 201

Chain	Residue
H	ARG22

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	160
Details	TRANSMEM: Helical; Name=Outer helix M1

Chain	Residue	Details
D	THR21-ILE41
C	THR21-ILE41
A	THR21-ILE41
B	THR21-ILE41
E	THR21-ILE41
F	THR21-ILE41
G	THR21-ILE41
H	THR21-ILE41

---

site_id	SWS_FT_FI2
Number of Residues	80
Details	TOPO_DOM: Extracellular

Chain	Residue	Details
D	GLU42-VAL48
E	TYR65-THR69
F	GLU42-VAL48
F	TYR65-THR69
G	GLU42-VAL48
G	TYR65-THR69
H	GLU42-VAL48
H	TYR65-THR69
D	TYR65-THR69
C	GLU42-VAL48
C	TYR65-THR69
A	GLU42-VAL48
A	TYR65-THR69
B	GLU42-VAL48
B	TYR65-THR69
E	GLU42-VAL48

---

site_id	SWS_FT_FI3
Number of Residues	72
Details	INTRAMEM: Helical; Pore-forming => ECO:0000255

Chain	Residue	Details
D	SER49-ALA58
C	SER49-ALA58
A	SER49-ALA58
B	SER49-ALA58
E	SER49-ALA58
F	SER49-ALA58
G	SER49-ALA58
H	SER49-ALA58

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	INTRAMEM: Pore-forming => ECO:0000255

Chain	Residue	Details
D	THR59-ASP64
C	THR59-ASP64
A	THR59-ASP64
B	THR59-ASP64
E	THR59-ASP64
F	THR59-ASP64
G	THR59-ASP64
H	THR59-ASP64

---

site_id	SWS_FT_FI5
Number of Residues	200
Details	TRANSMEM: Helical; Name=Inner helix M2

Chain	Residue	Details
D	PRO70-LEU95
C	PRO70-LEU95
A	PRO70-LEU95
B	PRO70-LEU95
E	PRO70-LEU95
F	PRO70-LEU95
G	PRO70-LEU95
H	PRO70-LEU95

---