Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4HZ0

Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003918molecular_functionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A0005524molecular_functionATP binding
A0005694cellular_componentchromosome
A0006265biological_processDNA topological change
B0003677molecular_functionDNA binding
B0003918molecular_functionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B0005524molecular_functionATP binding
B0005694cellular_componentchromosome
B0006265biological_processDNA topological change
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 1AV A 301
ChainResidue
AASN42
AHOH430
AHOH446
ASER43
AGLU46
AASP69
AARG72
AGLY73
APRO75
AILE90
AHOH414

site_idAC2
Number of Residues1
DetailsBINDING SITE FOR RESIDUE MG A 302
ChainResidue
AHIS186

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 1AV B 301
ChainResidue
BASN42
BSER43
BGLU46
BASP69
BARG72
BGLY73
BMET74
BILE90
BHOH404
BHOH417

site_idAC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MG B 302
ChainResidue
BHIS186
BHOH498

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000305|PubMed:15105144
ChainResidueDetails
AASN42
AASP69
AGLY110
BASN42
BASP69
BGLY110

224201

PDB entries from 2024-08-28

PDB statisticsPDBj update infoContact PDBjnumon