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4HXZ

Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003918molecular_functionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A0005524molecular_functionATP binding
A0005694cellular_componentchromosome
A0006265biological_processDNA topological change
B0003677molecular_functionDNA binding
B0003918molecular_functionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B0005524molecular_functionATP binding
B0005694cellular_componentchromosome
B0006265biological_processDNA topological change
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 19Y A 1401
ChainResidue
AILE38
AILE164
AHOH1543
AASN41
ASER42
AGLU45
AASP68
AGLY72
AMET73
AVAL115
ATHR162

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE 19Y B 1401
ChainResidue
BILE38
BASN41
BSER42
BGLU45
BASP68
BARG71
BGLY72
BMET73
BPRO74
BVAL115
BTHR162
BILE164
BHOH1541
BHOH1561

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00938
ChainResidueDetails
ATYR4
BLYS333
AASN41
AASP68
AGLY109
ALYS333
BTYR4
BASN41
BASP68
BGLY109

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PDB entries from 2024-11-06

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