4HXW

Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 1A0 A 301

Chain	Residue
A	ASN55
A	THR174
A	HOH414
A	HOH484
A	SER56
A	GLU59
A	ASP82
A	ARG85
A	GLY86
A	ILE87
A	PRO88
A	SER129

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE TBU A 302

Chain	Residue
A	ALA60
A	THR137
A	ARG155
A	ARG156
A	ASN207
A	ARG208
A	HOH586

---