4HXG
Pyrococcus horikoshii acylaminoacyl peptidase (orthorhombic crystal form)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0004252 | molecular_function | serine-type endopeptidase activity |
| E | 0006508 | biological_process | proteolysis |
| E | 0008233 | molecular_function | peptidase activity |
| E | 0008236 | molecular_function | serine-type peptidase activity |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0004252 | molecular_function | serine-type endopeptidase activity |
| F | 0006508 | biological_process | proteolysis |
| F | 0008233 | molecular_function | peptidase activity |
| F | 0008236 | molecular_function | serine-type peptidase activity |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0004252 | molecular_function | serine-type endopeptidase activity |
| G | 0006508 | biological_process | proteolysis |
| G | 0008233 | molecular_function | peptidase activity |
| G | 0008236 | molecular_function | serine-type peptidase activity |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0004252 | molecular_function | serine-type endopeptidase activity |
| H | 0006508 | biological_process | proteolysis |
| H | 0008233 | molecular_function | peptidase activity |
| H | 0008236 | molecular_function | serine-type peptidase activity |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0004252 | molecular_function | serine-type endopeptidase activity |
| I | 0006508 | biological_process | proteolysis |
| I | 0008233 | molecular_function | peptidase activity |
| I | 0008236 | molecular_function | serine-type peptidase activity |
| I | 0016787 | molecular_function | hydrolase activity |
| I | 0046872 | molecular_function | metal ion binding |
| J | 0004252 | molecular_function | serine-type endopeptidase activity |
| J | 0006508 | biological_process | proteolysis |
| J | 0008233 | molecular_function | peptidase activity |
| J | 0008236 | molecular_function | serine-type peptidase activity |
| J | 0016787 | molecular_function | hydrolase activity |
| J | 0046872 | molecular_function | metal ion binding |
| K | 0004252 | molecular_function | serine-type endopeptidase activity |
| K | 0006508 | biological_process | proteolysis |
| K | 0008233 | molecular_function | peptidase activity |
| K | 0008236 | molecular_function | serine-type peptidase activity |
| K | 0016787 | molecular_function | hydrolase activity |
| K | 0046872 | molecular_function | metal ion binding |
| L | 0004252 | molecular_function | serine-type endopeptidase activity |
| L | 0006508 | biological_process | proteolysis |
| L | 0008233 | molecular_function | peptidase activity |
| L | 0008236 | molecular_function | serine-type peptidase activity |
| L | 0016787 | molecular_function | hydrolase activity |
| L | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE HEZ A 701 |
| Chain | Residue |
| A | GLY387 |
| A | ALA466 |
| A | TYR467 |
| A | ILE491 |
| A | SER497 |
| A | SER501 |
| A | ARG548 |
| A | CYS549 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HEZ A 702 |
| Chain | Residue |
| A | HOH807 |
| A | LYS397 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HEZ A 703 |
| Chain | Residue |
| A | GLN266 |
| A | TRP302 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 704 |
| Chain | Residue |
| A | LYS99 |
| A | GLU162 |
| A | HOH938 |
| A | HOH949 |
| C | GLU42 |
| C | HOH841 |
| C | HOH858 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 705 |
| Chain | Residue |
| A | ASP244 |
| A | GLU263 |
| A | HOH812 |
| A | HOH947 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE HEZ B 701 |
| Chain | Residue |
| B | GLY386 |
| B | GLY387 |
| B | ALA466 |
| B | TYR467 |
| B | SER497 |
| B | SER501 |
| B | ARG548 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE HEZ B 702 |
| Chain | Residue |
| B | LEU544 |
| B | ASP546 |
| B | LEU551 |
| E | LEU544 |
| E | ASP546 |
| E | PRO550 |
| E | LEU551 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 703 |
| Chain | Residue |
| A | GLU42 |
| A | HOH853 |
| A | HOH854 |
| B | LYS99 |
| B | GLU162 |
| B | HOH828 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HEZ C 701 |
| Chain | Residue |
| C | GLY387 |
| C | ALA466 |
| C | TYR467 |
| C | SER497 |
| C | SER501 |
| C | ILE503 |
| C | PHE507 |
| C | ASP508 |
| C | ARG548 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 702 |
| Chain | Residue |
| B | GLU42 |
| B | HOH829 |
| C | LYS99 |
| C | GLU162 |
| C | HOH801 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 703 |
| Chain | Residue |
| C | ASP244 |
| C | GLU263 |
| C | HOH802 |
| C | HOH810 |
| C | HOH857 |
| C | HOH859 |
| site_id | BC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE HEZ D 701 |
| Chain | Residue |
| D | GLY387 |
| D | ALA466 |
| D | TYR467 |
| D | ILE491 |
| D | SER497 |
| D | SER501 |
| D | ARG548 |
| D | HIS578 |
| D | HEZ707 |
| D | HOH1013 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE HEZ D 702 |
| Chain | Residue |
| A | LEU544 |
| A | ASP546 |
| A | PRO550 |
| A | LEU551 |
| D | LEU544 |
| D | ASP546 |
| D | LEU551 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE HEZ D 703 |
| Chain | Residue |
| D | TYR239 |
| D | ASP424 |
| D | LEU427 |
| D | ARG428 |
| D | HOH869 |
| D | HOH900 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HEZ D 704 |
| Chain | Residue |
| D | TYR16 |
| D | TYR41 |
| D | ARG583 |
| D | ARG589 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HEZ D 705 |
| Chain | Residue |
| D | LYS535 |
| D | TYR607 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE HEZ D 706 |
| Chain | Residue |
| D | TYR220 |
| D | ALA265 |
| D | GLN266 |
| D | ALA267 |
| D | HOH826 |
| D | HOH920 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HEZ D 707 |
| Chain | Residue |
| D | HIS578 |
| D | SER581 |
| D | HEZ701 |
| D | ALA466 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE HEZ D 708 |
| Chain | Residue |
| D | SER241 |
| D | PRO388 |
| D | LYS389 |
| D | PHE507 |
| D | VAL511 |
| D | HOH938 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 709 |
| Chain | Residue |
| D | ASP244 |
| D | GLU263 |
| D | HOH802 |
| D | HOH935 |
| D | HOH936 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 710 |
| Chain | Residue |
| D | LYS99 |
| D | GLU162 |
| D | HOH1021 |
| E | GLU42 |
| E | HOH832 |
| E | HOH902 |
| site_id | CC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL D 711 |
| Chain | Residue |
| D | ARG55 |
| F | GLU160 |
| site_id | CC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE HEZ E 701 |
| Chain | Residue |
| E | GLY386 |
| E | GLY387 |
| E | ALA466 |
| E | TYR467 |
| E | ILE491 |
| E | SER497 |
| E | SER501 |
| E | ARG548 |
| site_id | CC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE HEZ E 702 |
| Chain | Residue |
| E | LYS316 |
| E | GLU317 |
| E | ARG321 |
| E | PRO322 |
| E | GLU324 |
| E | TYR326 |
| E | GLN334 |
| site_id | CC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HEZ E 703 |
| Chain | Residue |
| E | TYR16 |
| E | ARG589 |
| site_id | CC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG E 704 |
| Chain | Residue |
| E | TYR232 |
| E | ASP244 |
| E | GLU263 |
| E | HOH801 |
| E | HOH842 |
| E | HOH987 |
| site_id | CC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG E 705 |
| Chain | Residue |
| E | LYS99 |
| E | GLU162 |
| E | HOH919 |
| F | GLU42 |
| F | HOH871 |
| F | HOH872 |
| F | HOH873 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG E 706 |
| Chain | Residue |
| D | HOH915 |
| D | HOH1006 |
| E | HOH896 |
| E | HOH901 |
| E | HOH946 |
| site_id | DC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HEZ F 701 |
| Chain | Residue |
| F | GLY387 |
| F | ALA466 |
| F | TYR467 |
| F | ILE491 |
| F | SER497 |
| F | SER501 |
| F | PHE507 |
| F | ASP508 |
| F | ARG548 |
| site_id | DC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE HEZ F 702 |
| Chain | Residue |
| C | LEU544 |
| F | LEU544 |
| F | ASP546 |
| F | PRO550 |
| F | LEU551 |
| site_id | DC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE HEZ F 703 |
| Chain | Residue |
| F | TYR220 |
| F | TYR232 |
| F | ALA265 |
| F | GLN266 |
| F | ALA267 |
| site_id | DC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG F 704 |
| Chain | Residue |
| F | ASP244 |
| F | GLU263 |
| F | HOH802 |
| F | HOH878 |
| F | HOH954 |
| site_id | DC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG F 705 |
| Chain | Residue |
| D | GLU42 |
| D | HOH856 |
| D | HOH939 |
| D | HOH940 |
| F | LYS99 |
| F | GLU162 |
| F | HOH879 |
| site_id | DC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG F 706 |
| Chain | Residue |
| E | GLU163 |
| E | HOH840 |
| E | HOH841 |
| E | HOH979 |
| E | HOH988 |
| F | GLU37 |
| F | HOH955 |
| site_id | DC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL F 707 |
| Chain | Residue |
| E | LYS98 |
| F | ARG55 |
| site_id | DC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE HEZ G 701 |
| Chain | Residue |
| G | GLY387 |
| G | ALA466 |
| G | TYR467 |
| G | ILE491 |
| G | SER497 |
| G | SER501 |
| G | PHE507 |
| G | ARG548 |
| site_id | EC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG G 702 |
| Chain | Residue |
| G | LYS99 |
| G | GLU162 |
| G | HOH827 |
| G | HOH875 |
| I | GLU42 |
| I | HOH808 |
| I | HOH875 |
| site_id | EC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG G 703 |
| Chain | Residue |
| G | ASP244 |
| G | GLU263 |
| G | HOH804 |
| G | HOH810 |
| site_id | EC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HEZ H 701 |
| Chain | Residue |
| H | GLY386 |
| H | GLY387 |
| H | ALA466 |
| H | TYR467 |
| H | SER497 |
| H | SER501 |
| H | PHE507 |
| H | ASP508 |
| H | ARG548 |
| site_id | EC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG H 702 |
| Chain | Residue |
| H | ASP244 |
| H | GLU263 |
| H | HOH802 |
| H | HOH818 |
| H | HOH856 |
| H | HOH857 |
| site_id | EC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG H 703 |
| Chain | Residue |
| G | GLU42 |
| G | HOH828 |
| G | HOH876 |
| H | LYS99 |
| H | GLU162 |
| H | HOH801 |
| H | HOH808 |
| site_id | EC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE HEZ I 701 |
| Chain | Residue |
| I | GLY387 |
| I | ALA466 |
| I | TYR467 |
| I | ILE491 |
| I | SER497 |
| I | SER501 |
| I | PHE507 |
| I | ARG548 |
| site_id | EC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HEZ I 702 |
| Chain | Residue |
| I | ASP480 |
| I | LYS483 |
| I | LYS535 |
| I | TYR607 |
| site_id | EC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG I 703 |
| Chain | Residue |
| H | GLU42 |
| H | HOH858 |
| I | LYS99 |
| I | GLU162 |
| I | HOH833 |
| I | HOH834 |
| site_id | EC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG I 704 |
| Chain | Residue |
| I | ASP244 |
| I | GLU263 |
| I | HOH803 |
| I | HOH871 |
| I | HOH876 |
| I | HOH877 |
| site_id | FC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE HEZ K 701 |
| Chain | Residue |
| K | GLY386 |
| K | GLY387 |
| K | ALA466 |
| K | TYR467 |
| K | SER497 |
| K | SER501 |
| K | ARG548 |
| site_id | FC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE HEZ L 701 |
| Chain | Residue |
| L | GLY387 |
| L | ALA466 |
| L | TYR467 |
| L | SER497 |
| L | SER501 |
| L | PHE507 |
| L | ARG548 |
| site_id | FC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG L 702 |
| Chain | Residue |
| L | ASP244 |
| L | GLU263 |
| L | HOH809 |
| L | HOH820 |
| L | HOH851 |
| site_id | FC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG L 703 |
| Chain | Residue |
| J | THR44 |
| J | GLU59 |
| J | HOH706 |
| J | HOH707 |
| L | LYS99 |
| L | GLU162 |
