4HX3

Crystal structure of Streptomyces caespitosus sermetstatin in complex with S. caespitosus snapalysin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0005576	cellular_component	extracellular region
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0046872	molecular_function	metal ion binding
B	0004867	molecular_function	serine-type endopeptidase inhibitor activity
B	0005576	cellular_component	extracellular region
B	0046872	molecular_function	metal ion binding
C	0004222	molecular_function	metalloendopeptidase activity
C	0005576	cellular_component	extracellular region
C	0006508	biological_process	proteolysis
C	0008237	molecular_function	metallopeptidase activity
C	0008270	molecular_function	zinc ion binding
C	0046872	molecular_function	metal ion binding
D	0004867	molecular_function	serine-type endopeptidase inhibitor activity
D	0005576	cellular_component	extracellular region
D	0046872	molecular_function	metal ion binding
E	0004222	molecular_function	metalloendopeptidase activity
E	0005576	cellular_component	extracellular region
E	0006508	biological_process	proteolysis
E	0008237	molecular_function	metallopeptidase activity
E	0008270	molecular_function	zinc ion binding
E	0046872	molecular_function	metal ion binding
F	0004867	molecular_function	serine-type endopeptidase inhibitor activity
F	0005576	cellular_component	extracellular region
F	0046872	molecular_function	metal ion binding
G	0004222	molecular_function	metalloendopeptidase activity
G	0005576	cellular_component	extracellular region
G	0006508	biological_process	proteolysis
G	0008237	molecular_function	metallopeptidase activity
G	0008270	molecular_function	zinc ion binding
G	0046872	molecular_function	metal ion binding
H	0004867	molecular_function	serine-type endopeptidase inhibitor activity
H	0005576	cellular_component	extracellular region
H	0046872	molecular_function	metal ion binding
I	0004222	molecular_function	metalloendopeptidase activity
I	0005576	cellular_component	extracellular region
I	0006508	biological_process	proteolysis
I	0008237	molecular_function	metallopeptidase activity
I	0008270	molecular_function	zinc ion binding
I	0046872	molecular_function	metal ion binding
J	0004867	molecular_function	serine-type endopeptidase inhibitor activity
J	0005576	cellular_component	extracellular region
J	0046872	molecular_function	metal ion binding
K	0004222	molecular_function	metalloendopeptidase activity
K	0005576	cellular_component	extracellular region
K	0006508	biological_process	proteolysis
K	0008237	molecular_function	metallopeptidase activity
K	0008270	molecular_function	zinc ion binding
K	0046872	molecular_function	metal ion binding
L	0004867	molecular_function	serine-type endopeptidase inhibitor activity
L	0005576	cellular_component	extracellular region
L	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 201

Chain	Residue
A	HIS83
A	HIS87
A	ASP93
A	HOH323

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 201

Chain	Residue
C	HIS83
C	HIS87
C	ASP93
C	HOH302

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 201

Chain	Residue
D	ALA41
D	PRO42
D	ARG43
D	ALA44
C	GLN96

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 201

Chain	Residue
E	HIS83
E	HIS87
E	ASP93
E	HOH309

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 201

Chain	Residue
G	HIS83
G	HIS87
G	ASP93
G	HOH311

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 201

Chain	Residue
I	HIS83
I	HIS87
I	ASP93
I	HOH312

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL J 501

Chain	Residue
D	GLN14
D	THR20
D	THR22
J	THR20
J	ASP21
J	HOH621

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 201

Chain	Residue
K	HIS83
K	HIS87
K	ASP93
K	HOH301

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE:

Chain	Residue	Details
A	GLU84
C	GLU84
E	GLU84
G	GLU84
I	GLU84
K	GLU84

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	BINDING: BINDING => ECO:0000269|PubMed:9089404

Chain	Residue	Details
A	ASP76
C	ASP93
E	ASP76
E	THR78
E	HIS83
E	HIS87
E	ASP93
G	ASP76
G	THR78
G	HIS83
G	HIS87
A	THR78
G	ASP93
I	ASP76
I	THR78
I	HIS83
I	HIS87
I	ASP93
K	ASP76
K	THR78
K	HIS83
K	HIS87
A	HIS83
K	ASP93
A	HIS87
A	ASP93
C	ASP76
C	THR78
C	HIS83
C	HIS87

---