4HX2

Crystal structure of Streptomyces caespitosus sermetstatin in complex with Bacillus licheniformis subtilisin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
B	0004867	molecular_function	serine-type endopeptidase inhibitor activity
B	0005576	cellular_component	extracellular region
B	0030414	molecular_function	peptidase inhibitor activity
B	0046872	molecular_function	metal ion binding
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis
C	0008236	molecular_function	serine-type peptidase activity
D	0004867	molecular_function	serine-type endopeptidase inhibitor activity
D	0005576	cellular_component	extracellular region
D	0030414	molecular_function	peptidase inhibitor activity
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 301

Chain	Residue
A	GLN2
A	ASP41
A	LEU75
A	ASN77
A	THR79
A	VAL81

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 302

Chain	Residue
A	HOH420
A	HOH423
A	ALA169
A	TYR171
A	VAL174

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 303

Chain	Residue
A	HIS238
A	GLN275
A	HOH476
C	GLU112

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site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 304

Chain	Residue
A	TYR209

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 1AX A 305

Chain	Residue
A	ASN25
A	GLY118
A	MET119
A	ASP120
A	ARG145
A	GLY146
A	VAL147
A	PO4306
A	HOH525

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 306

Chain	Residue
A	ASP120
A	GLY146
A	PRO239
A	LEU241
A	1AX305

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 307

Chain	Residue
A	ARG186
A	TYR262
A	TYR263
A	HOH504

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IPA A 308

Chain	Residue
A	ALA37
A	HIS39
A	LEU42
A	ASN43
A	HOH449
A	HOH543

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 501

Chain	Residue
B	HIS3
B	CAC504
B	HOH645
C	ASP120

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K B 502

Chain	Residue
B	HIS93
B	ASN104
B	HOH652

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE K B 503

Chain	Residue
B	HIS93
B	HOH629

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CAC B 504

Chain	Residue
B	ALA2
B	HIS3
B	ASN85
B	ARG87
B	ZN501
B	HOH645
C	GLY118
C	ASP120

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 301

Chain	Residue
C	GLN2
C	ASP41
C	LEU75
C	ASN77
C	THR79
C	VAL81

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 302

Chain	Residue
C	ALA169
C	TYR171
C	VAL174
C	HOH401
C	HOH447

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT C 303

Chain	Residue
C	LYS27
C	TYR91
C	ASN117
C	HOH414

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL C 304

Chain	Residue
C	ARG186
C	TYR262

---

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IPA C 305

Chain	Residue
C	ASN62
C	TYR209
D	TYR72

---

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IPA D 201

Chain	Residue
D	HIS93
D	THR94
D	ASN104

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Functional Information from PROSITE/UniProt

site_id	PS00136
Number of Residues	12
Details	SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. VAVLDTGIqasH

Chain	Residue	Details
A	VAL28-HIS39

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site_id	PS00137
Number of Residues	11
Details	SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGThVAGtVAA

Chain	Residue	Details
A	HIS64-ALA74

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site_id	PS00138
Number of Residues	11
Details	SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSmAsPhVAG

Chain	Residue	Details
A	GLY219-GLY229

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