4HWT
Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004829 | molecular_function | threonine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006435 | biological_process | threonyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004829 | molecular_function | threonine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006435 | biological_process | threonyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 801 |
| Chain | Residue |
| A | CYS446 |
| A | HIS497 |
| A | HIS623 |
| A | 1B2802 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 1B2 A 802 |
| Chain | Residue |
| A | HIS497 |
| A | TYR573 |
| A | ASP578 |
| A | ILE579 |
| A | GLN590 |
| A | CYS591 |
| A | ALA592 |
| A | GLN595 |
| A | HIS623 |
| A | ZN801 |
| A | HOH918 |
| A | MET444 |
| A | CYS446 |
| A | ARG475 |
| A | GLN493 |
| A | ASP495 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 801 |
| Chain | Residue |
| B | CYS446 |
| B | HIS497 |
| B | HIS623 |
| B | 1B2802 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 1B2 B 802 |
| Chain | Residue |
| B | MET444 |
| B | CYS446 |
| B | ARG475 |
| B | GLN493 |
| B | ASP495 |
| B | HIS497 |
| B | TYR573 |
| B | LYS576 |
| B | ASP578 |
| B | ILE579 |
| B | GLN590 |
| B | CYS591 |
| B | ALA592 |
| B | THR593 |
| B | GLN595 |
| B | HIS623 |
| B | ZN801 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR486 | |
| B | THR486 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER735 | |
| B | SER735 |
