4HUS

Crystal structure of streptogramin group A antibiotic acetyltransferase VatA from Staphylococcus aureus in complex with virginiamycin M1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0046677	biological_process	response to antibiotic
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0046677	biological_process	response to antibiotic
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 301

Chain	Residue
A	ARG70
A	LEU189
A	MET191
A	HOH503

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	ASN203
C	ARG88
C	ASP112
C	EDO307

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 303

Chain	Residue
A	LEU166
A	LYS167
A	PHE168
A	HOH478
A	LYS153

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 304

Chain	Residue
A	ASN164
A	HOH422
B	ASN164
B	HOH417
C	ASN164
C	HOH514

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 305

Chain	Residue
A	GLY117
A	ASP118
A	LYS138

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 306

Chain	Residue
A	ARG100
A	HOH518

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 307

Chain	Residue
A	LYS171

---

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 308

Chain	Residue
A	GLU60

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 309

Chain	Residue
A	GLY84
A	LEU216

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 310

Chain	Residue
A	LYS46
A	ARG47

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 311

Chain	Residue
A	ASP53
A	THR79
A	HOH420
A	HOH532
B	CL306

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 312

Chain	Residue
A	LYS138
A	GLY140
A	VAL155
A	HOH562

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG A 313

Chain	Residue
A	GLU12
A	LYS27
A	PRO28
A	HOH522
B	ARG211

---

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PEG A 314

Chain	Residue
A	PRO76
A	GLY128
A	ARG129
A	ALA146
A	ALA147
A	HOH410
C	TYR57
C	HOH511

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG A 315

Chain	Residue
A	ALA146
A	HOH454

---

site_id	BC7
Number of Residues	17
Details	BINDING SITE FOR RESIDUE VIR A 316

Chain	Residue
A	ASN20
A	LEU23
A	TYR42
A	ASP44
A	HOH410
A	HOH412
A	HOH488
A	HOH588
C	TYR59
C	GLY84
C	ASN86
C	HIS87
C	HIS97
C	LEU98
C	PRO108
C	LEU113
C	HOH571

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 301

Chain	Residue
B	LYS153
B	LEU166
B	LYS167
B	PHE168
B	HOH553

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 302

Chain	Residue
B	LYS27
B	GLY38
B	GLU39
B	ARG70
B	HOH449

---

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 303

Chain	Residue
B	ARG88
C	ASN203

---

site_id	CC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 304

Chain	Residue
B	ILE139

---

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 305

Chain	Residue
B	SER174
B	GLY176

---

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 306

Chain	Residue
A	EDO311
B	LYS46
B	ARG47

---

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 307

Chain	Residue
B	LYS214
B	HOH527

---

site_id	CC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 308

Chain	Residue
B	TRP126
B	GLY128
B	ALA146
B	ALA147
B	PEG312
B	PGE314
B	HOH471

---

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 309

Chain	Residue
B	HOH531
B	ASN154

---

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 310

Chain	Residue
B	GLU39
B	ARG70
B	LEU189
B	MET191

---

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 311

Chain	Residue
B	TYR57
B	TYR59

---

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG B 312

Chain	Residue
B	ALA146
B	EDO308
B	HOH537

---

site_id	DC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PGE B 313

Chain	Residue
B	HIS87
B	LEU98
C	TYR42
C	ASP44
C	HOH506
C	HOH529
C	HOH632

---

site_id	DC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PGE B 314

Chain	Residue
A	TYR57
A	HIS87
A	HOH476
B	TYR42
B	ASP44
B	GLY75
B	TRP126
B	ILE127
B	ARG129
B	EDO308
B	HOH471

---

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 301

Chain	Residue
C	LYS27
C	GLU39
C	ARG70
C	HOH579

---

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 302

Chain	Residue
C	LYS153
C	LYS167
C	PHE168
C	HOH615

---

site_id	DC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 303

Chain	Residue
C	ARG47

---

site_id	DC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 304

Chain	Residue
C	ARG100

---

site_id	DC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO C 305

Chain	Residue
C	ALA146
C	ILE160

---

site_id	DC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 306

Chain	Residue
C	ASN13
C	ASN13
C	ILE14
C	ILE14

---

site_id	EC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO C 307

Chain	Residue
A	PRO199
A	SO4302
C	MET107

---

site_id	EC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 308

Chain	Residue
C	LYS111
C	GLN185
C	ASN188
C	HOH604

---

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 309

Chain	Residue
C	ASP10
C	PRO11
C	GLU39
C	HOH611

---

site_id	EC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 310

Chain	Residue
C	GLU33
C	GLU33
C	ASN34
C	ASN34
C	GLU60
C	GLU60

---

Functional Information from PROSITE/UniProt

site_id	PS00101
Number of Residues	29
Details	HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IGrdVtImpgVkIGdgAiIAaeAvVtknV

Chain	Residue	Details
A	ILE127-VAL155

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---