Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4HUR

Crystal structure of streptogramin group A antibiotic acetyltransferase VatA from Staphylococcus aureus in complex with acetyl coenzyme A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0046677	biological_process	response to antibiotic
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0046677	biological_process	response to antibiotic
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ACO A 301

Chain	Residue
A	TYR42
A	GLY162
A	GLY163
A	ILE169
A	ARG170
A	HOH402
A	HOH472
A	HOH550
A	HOH575
B	TYR57
B	ALA85
A	SER73
B	ASN86
B	HIS87
B	LYS116
B	THR152
B	PRO165
B	HOH405
B	HOH463
A	ILE74
A	GLY75
A	TRP126
A	GLY128
A	ARG129
A	ALA146
A	ALA147

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	LYS27
A	GLY38
A	GLU39
A	ARG70
A	HOH432
A	HOH446

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 303

Chain	Residue
A	LYS153
A	LYS167
A	PHE168

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 304

Chain	Residue
A	ARG88
A	ASP112
C	ASN203

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 305

Chain	Residue
A	TYR59
A	GLU60
A	HOH454

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 306

Chain	Residue
A	LYS153
A	ASN154

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 307

Chain	Residue
A	ASN123
A	TRP187
A	ASN188
A	HOH537

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 308

Chain	Residue
A	GLU39
A	TYR40
A	ARG70
A	TRP187
A	LEU189
A	MET191

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 309

Chain	Residue
A	ILE193
A	ASN197
A	LYS212
A	LEU216

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 310

Chain	Residue
A	GLY140
A	ASN154
A	VAL155
A	ALA156
A	PRO157
A	HOH500

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 311

Chain	Residue
A	ARG211
A	HOH508
A	HOH566
B	LYS27
B	HOH420

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 312

Chain	Residue
A	GLU120
A	GLY122
A	ILE139
A	HOH420
A	HOH500

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 313

Chain	Residue
A	ARG129
A	HOH585
B	ASP53
B	GLN54

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 314

Chain	Residue
A	GLY117
A	ASP118
A	LYS138

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 315

Chain	Residue
A	LYS138

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 316

Chain	Residue
A	ASN164
A	HOH426
B	ASN164
B	HOH502
C	ASN164
C	HOH422

site_id	BC8
Number of Residues	28
Details	BINDING SITE FOR RESIDUE ACO B 301

Chain	Residue
B	ILE169
B	ARG170
B	HOH408
B	HOH466
B	HOH496
B	HOH511
C	TYR57
C	ALA85
C	ASN86
C	HIS87
C	LYS116
C	MET134
C	THR152
C	PRO165
C	HOH429
C	HOH466
B	TYR42
B	SER73
B	ILE74
B	GLY75
B	TRP126
B	ILE127
B	GLY128
B	ARG129
B	ALA146
B	ALA147
B	GLY162
B	GLY163

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO B 302

Chain	Residue
A	HOH583
B	GLU39
B	ARG70
B	TRP187
B	LEU189
B	MET191
B	ILE194
B	HOH564

site_id	CC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO B 303

Chain	Residue
A	MET208
B	LEU36
B	GLY38
B	ILE67
B	ILE68
B	GLY69
B	HOH409
B	HOH462

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 304

Chain	Residue
A	ASN203
B	ARG88
B	LEU189
B	ASP190
B	ILE193
B	HOH460

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 305

Chain	Residue
B	PRO9
B	ASP10
B	HOH562

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 306

Chain	Residue
B	LYS153
B	LYS167
B	PHE168

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO B 307

Chain	Residue
B	VAL155

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 308

Chain	Residue
B	GLY117
B	ASP118
B	LYS138
B	HOH597

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 309

Chain	Residue
A	HOH593
B	TYR57
B	HOH520

site_id	CC8
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ACO C 301

Chain	Residue
A	TYR57
A	ALA85
A	ASN86
A	LYS116
A	MET134
A	THR152
A	PRO165
A	HOH538
C	TYR42
C	SER73
C	ILE74
C	GLY75
C	TRP126
C	ILE127
C	GLY128
C	ARG129
C	ALA146
C	ALA147
C	GLY162
C	GLY163
C	ILE169
C	ARG170
C	HOH401
C	HOH443
C	HOH460
C	HOH561

site_id	CC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 302

Chain	Residue
C	LYS27
C	GLY38
C	GLU39
C	ARG70
C	HOH456
C	HOH533
C	HOH548

site_id	DC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO C 303

Chain	Residue
C	LYS167
C	PHE168

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 304

Chain	Residue
C	ILE30
C	THR31
C	ASN32
C	HOH600

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 305

Chain	Residue
C	GLU120
C	GLY122
C	ILE139
C	GLY140

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 306

Chain	Residue
C	SER109
C	LEU110
C	LYS111
C	HOH612

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO C 307

Chain	Residue
C	GLU33
C	ASN34
C	LEU36
C	VAL61
C	LYS65

site_id	DC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 308

Chain	Residue
C	ASN123
C	GLN185
C	TRP187
C	ASN188

site_id	DC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO C 309

Chain	Residue
B	ASN203
C	ARG88
C	HOH557

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 310

Chain	Residue
B	HOH511
C	PRO95
C	HIS97
C	HOH442

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO C 311

Chain	Residue
B	ARG129
C	ASP53
C	GLN54
C	THR79
C	HOH415

Functional Information from PROSITE/UniProt

site_id	PS00101
Number of Residues	29
Details	HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IGrdVtImpgVkIGdgAiIAaeAvVtknV

Chain	Residue	Details
A	ILE127-VAL155

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	HIS87
B	HIS87
C	HIS87

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)