4HTG

Porphobilinogen Deaminase from Arabidopsis Thaliana

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004418	molecular_function	hydroxymethylbilane synthase activity
A	0018160	biological_process	peptidyl-pyrromethane cofactor linkage
A	0033014	biological_process	tetrapyrrole biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE 18W A 401

Chain	Residue
A	ARG18
A	ARG142
A	ARG143
A	ARG161
A	GLY162
A	ASN163
A	VAL164
A	ARG167
A	ALA207
A	CYS254
A	HOH514
A	SER20
A	HOH651
A	HOH782
A	HOH881
A	LEU64
A	PHE73
A	LYS94
A	ASP95
A	THR138
A	ALA139
A	SER140

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 402

Chain	Residue
A	LYS94
A	ARG143
A	LEU181
A	ALA182
A	HOH517
A	HOH728

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Functional Information from PROSITE/UniProt

site_id	PS00533
Number of Residues	17
Details	PORPHOBILINOGEN_DEAM Porphobilinogen deaminase cofactor-binding site. ERaFletLdGSCrTPIA

Chain	Residue	Details
A	GLU243-ALA259

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"23519422","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23519422","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4HTG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19376835","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"S-(dipyrrolylmethanemethyl)cysteine","evidences":[{"source":"PubMed","id":"23519422","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4HTG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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