4HRR

Scapharca tetrameric hemoglobin, CO-state

Replaces:  1SCT

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005344	molecular_function	oxygen carrier activity
A	0015671	biological_process	oxygen transport
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0046872	molecular_function	metal ion binding
B	0005344	molecular_function	oxygen carrier activity
B	0015671	biological_process	oxygen transport
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0046872	molecular_function	metal ion binding
C	0005344	molecular_function	oxygen carrier activity
C	0015671	biological_process	oxygen transport
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0046872	molecular_function	metal ion binding
D	0005344	molecular_function	oxygen carrier activity
D	0015671	biological_process	oxygen transport
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0046872	molecular_function	metal ion binding
E	0005344	molecular_function	oxygen carrier activity
E	0015671	biological_process	oxygen transport
E	0019825	molecular_function	oxygen binding
E	0020037	molecular_function	heme binding
E	0046872	molecular_function	metal ion binding
F	0005344	molecular_function	oxygen carrier activity
F	0015671	biological_process	oxygen transport
F	0019825	molecular_function	oxygen binding
F	0020037	molecular_function	heme binding
F	0046872	molecular_function	metal ion binding
G	0005344	molecular_function	oxygen carrier activity
G	0015671	biological_process	oxygen transport
G	0019825	molecular_function	oxygen binding
G	0020037	molecular_function	heme binding
G	0046872	molecular_function	metal ion binding
H	0005344	molecular_function	oxygen carrier activity
H	0015671	biological_process	oxygen transport
H	0019825	molecular_function	oxygen binding
H	0020037	molecular_function	heme binding
H	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEM A 201

Chain	Residue
A	TYR50
A	ARG104
A	ALA110
A	PHE111
A	CMO202
A	HOH306
A	HOH345
A	HOH386
A	HOH431
A	HOH449
A	HOH462
A	PHE51
B	LYS98
B	ASN102
A	ARG53
A	HIS69
A	LEU73
A	LEU77
A	PHE97
A	ASN100
A	HIS101

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CMO A 202

Chain	Residue
A	MET37
A	PHE51
A	HIS69
A	LEU73
A	HEM201

---

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEM B 201

Chain	Residue
A	LYS96
A	ASN100
B	LYS52
B	PHE53
B	ARG55
B	HIS71
B	LEU75
B	PHE99
B	ASN102
B	HIS103
B	ARG106
B	GLU112
B	PHE113
B	CMO202
B	HOH344
B	HOH380
B	HOH460

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CMO B 202

Chain	Residue
B	MET39
B	PHE53
B	HIS71
B	LEU75
B	HEM201

---

site_id	AC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEM C 201

Chain	Residue
C	TYR50
C	PHE51
C	ARG53
C	HIS69
C	LEU73
C	PHE97
C	HIS101
C	ARG104
C	ALA110
C	PHE111
C	CMO202
C	HOH322
C	HOH389
C	HOH391
C	HOH409
D	LYS98
D	ASN102
D	HEM201

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CMO C 202

Chain	Residue
C	PHE51
C	HIS69
C	LEU73
C	HEM201

---

site_id	AC7
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM D 201

Chain	Residue
C	LYS96
C	ASN100
C	HEM201
C	HOH391
D	LYS52
D	PHE53
D	ARG55
D	HIS71
D	LEU75
D	ASN102
D	HIS103
D	ARG106
D	ILE108
D	GLU112
D	PHE113
D	CMO202
D	HOH351
D	HOH354
D	HOH396
D	HOH536

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CMO D 202

Chain	Residue
D	PHE53
D	HIS71
D	HEM201

---

site_id	AC9
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM E 201

Chain	Residue
E	PHE97
E	ASN100
E	HIS101
E	ARG104
E	ILE106
E	ALA110
E	PHE111
E	CMO202
E	HOH310
E	HOH350
F	LYS98
F	ASN102
F	HOH376
F	HOH456
E	TYR50
E	PHE51
E	ARG53
E	HIS69
E	LEU73
E	LEU77

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CMO E 202

Chain	Residue
E	MET37
E	PHE51
E	HIS69
E	LEU73
E	HEM201

---

site_id	BC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM F 201

Chain	Residue
E	LYS96
E	ASN100
E	HOH353
F	LYS52
F	PHE53
F	ARG55
F	HIS71
F	LEU75
F	PHE99
F	ASN102
F	HIS103
F	ARG106
F	GLU112
F	PHE113
F	CMO202
F	HOH315
F	HOH391
F	HOH439
F	HOH456
F	HOH516

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CMO F 202

Chain	Residue
F	MET39
F	PHE53
F	HIS71
F	LEU75
F	HEM201

---

site_id	BC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEM G 201

Chain	Residue
G	THR47
G	TYR50
G	PHE51
G	ARG53
G	HIS69
G	LEU73
G	PHE97
G	ASN100
G	HIS101
G	ARG104
G	ALA110
G	PHE111
G	CMO202
G	HOH341
G	HOH384
G	HOH390
G	HOH549
H	LYS98
H	ASN102
H	HEM201
H	HOH386

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CMO G 202

Chain	Residue
G	HIS69
G	HIS101
G	HEM201

---

site_id	BC6
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM H 201

Chain	Residue
G	LYS96
G	ASN100
G	HEM201
G	HOH384
G	HOH441
H	LYS52
H	PHE53
H	ARG55
H	HIS71
H	LEU75
H	ASN102
H	HIS103
H	ARG106
H	GLU112
H	PHE113
H	CMO202
H	HOH329
H	HOH336
H	HOH419

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CMO H 202

Chain	Residue
H	PHE53
H	HIS71
H	HEM201

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"description":"proximal binding residue"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"UniProtKB","id":"P04251","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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