4HO8
Crystal structure of glucose 1-phosphate thymidylyltransferase from Aneurinibacillus thermoaerophilus complexed with UDP-glucose and thymidine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0045226 | biological_process | extracellular polysaccharide biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0045226 | biological_process | extracellular polysaccharide biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0016779 | molecular_function | nucleotidyltransferase activity |
| C | 0045226 | biological_process | extracellular polysaccharide biosynthetic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0016779 | molecular_function | nucleotidyltransferase activity |
| D | 0045226 | biological_process | extracellular polysaccharide biosynthetic process |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE UPG A 300 |
| Chain | Residue |
| A | LEU6 |
| A | LEU106 |
| A | ASP108 |
| A | PHE143 |
| A | GLY144 |
| A | GLU159 |
| A | LYS160 |
| A | VAL170 |
| A | ARG192 |
| A | TRP221 |
| A | HOH432 |
| A | GLY8 |
| A | HOH434 |
| A | GLY9 |
| A | LYS23 |
| A | GLN80 |
| A | PRO83 |
| A | ASP84 |
| A | GLY85 |
| A | LEU86 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE THM A 301 |
| Chain | Residue |
| A | LEU43 |
| A | TYR112 |
| A | GLY113 |
| A | ALA249 |
| A | GLU253 |
| A | ILE254 |
| A | SO4304 |
| A | HOH405 |
| A | HOH407 |
| A | HOH422 |
| B | ARG217 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 302 |
| Chain | Residue |
| A | SER10 |
| A | GLY11 |
| A | THR12 |
| A | ARG13 |
| A | HOH417 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 303 |
| Chain | Residue |
| A | GLY67 |
| A | GLY68 |
| A | SER69 |
| A | GLU70 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 304 |
| Chain | Residue |
| A | HIS114 |
| A | GLY115 |
| A | THM301 |
| B | GLY216 |
| B | ARG217 |
| B | GLY218 |
| site_id | AC6 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE UPG B 300 |
| Chain | Residue |
| B | LEU6 |
| B | GLY8 |
| B | GLY9 |
| B | LYS23 |
| B | GLN80 |
| B | PRO83 |
| B | ASP84 |
| B | GLY85 |
| B | LEU86 |
| B | LEU106 |
| B | ASP108 |
| B | ASN109 |
| B | PHE143 |
| B | GLY144 |
| B | GLU159 |
| B | LYS160 |
| B | VAL170 |
| B | ARG192 |
| B | SO4302 |
| B | HOH410 |
| B | HOH416 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE THM B 301 |
| Chain | Residue |
| A | ARG217 |
| B | LEU43 |
| B | TYR112 |
| B | GLY113 |
| B | ALA249 |
| B | GLU253 |
| B | ILE254 |
| B | SO4304 |
| B | HOH404 |
| B | HOH421 |
| B | HOH428 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 302 |
| Chain | Residue |
| B | SER10 |
| B | GLY11 |
| B | THR12 |
| B | ARG13 |
| B | UPG300 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 303 |
| Chain | Residue |
| B | GLY67 |
| B | GLY68 |
| B | SER69 |
| B | HOH433 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 304 |
| Chain | Residue |
| A | GLY216 |
| A | ARG217 |
| A | GLY218 |
| B | HIS114 |
| B | GLY115 |
| B | THM301 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 305 |
| Chain | Residue |
| A | ARG142 |
| B | LYS242 |
| B | ARG243 |
| site_id | BC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE UPG C 300 |
| Chain | Residue |
| C | LYS23 |
| C | GLN80 |
| C | PRO83 |
| C | ASP84 |
| C | GLY85 |
| C | LEU106 |
| C | ASP108 |
| C | ASN109 |
| C | PHE143 |
| C | GLY144 |
| C | GLU159 |
| C | LYS160 |
| C | VAL170 |
| C | ARG192 |
| C | SO4302 |
| C | HOH411 |
| C | LEU6 |
| C | GLY8 |
| C | GLY9 |
| site_id | BC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE THM C 301 |
| Chain | Residue |
| C | LEU43 |
| C | TYR112 |
| C | GLY113 |
| C | PHE116 |
| C | ALA249 |
| C | GLU253 |
| C | ILE254 |
| C | ARG257 |
| C | SO4304 |
| C | HOH414 |
| C | HOH420 |
| C | HOH426 |
| C | HOH431 |
| D | ARG217 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 302 |
| Chain | Residue |
| C | SER10 |
| C | GLY11 |
| C | THR12 |
| C | ARG13 |
| C | UPG300 |
| C | HOH415 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 303 |
| Chain | Residue |
| C | GLY66 |
| C | GLY67 |
| C | GLY68 |
| C | SER69 |
| C | GLU70 |
| C | HOH416 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 304 |
| Chain | Residue |
| C | HIS114 |
| C | GLY115 |
| C | THM301 |
| D | GLY216 |
| D | ARG217 |
| D | GLY218 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 305 |
| Chain | Residue |
| C | LYS242 |
| C | ARG243 |
| D | ARG142 |
| D | HOH423 |
| site_id | BC9 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE UPG D 300 |
| Chain | Residue |
| D | LEU6 |
| D | GLY8 |
| D | GLY9 |
| D | LYS23 |
| D | GLN80 |
| D | PRO83 |
| D | ASP84 |
| D | GLY85 |
| D | LEU86 |
| D | LEU106 |
| D | ASP108 |
| D | ASN109 |
| D | PHE143 |
| D | GLY144 |
| D | GLU159 |
| D | LYS160 |
| D | VAL170 |
| D | ARG192 |
| D | TRP221 |
| D | SO4302 |
| D | HOH435 |
| site_id | CC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE THM D 301 |
| Chain | Residue |
| C | ARG217 |
| D | LEU43 |
| D | TYR112 |
| D | GLY113 |
| D | VAL248 |
| D | ALA249 |
| D | GLU253 |
| D | ILE254 |
| D | SO4304 |
| D | HOH404 |
| D | HOH416 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 302 |
| Chain | Residue |
| D | GLY11 |
| D | THR12 |
| D | ARG13 |
| D | UPG300 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 303 |
| Chain | Residue |
| D | GLY67 |
| D | GLY68 |
| D | SER69 |
| D | GLU70 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 304 |
| Chain | Residue |
| C | GLY216 |
| C | ARG217 |
| C | GLY218 |
| D | HIS114 |
| D | GLY115 |
| D | THM301 |
