4HN2
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMPPNP and a substrate analog 5PA-IP5
Replaces: 4GB4Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000829 | molecular_function | inositol heptakisphosphate kinase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE ANP A 401 |
Chain | Residue |
A | ARG134 |
A | MET240 |
A | ASP246 |
A | LYS248 |
A | ARG262 |
A | SER264 |
A | ASP309 |
A | LEU311 |
A | CYS320 |
A | ASP321 |
A | ASN323 |
A | PRO149 |
A | 0EJ402 |
A | MG403 |
A | MG404 |
A | HOH571 |
A | HOH579 |
A | HOH737 |
A | HOH738 |
A | HOH778 |
A | LYS187 |
A | HIS194 |
A | LEU211 |
A | ARG213 |
A | GLU237 |
A | GLU238 |
A | PHE239 |
site_id | AC2 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE 0EJ A 402 |
Chain | Residue |
A | LYS53 |
A | LYS54 |
A | ARG213 |
A | LYS214 |
A | LYS248 |
A | ARG281 |
A | SER326 |
A | LYS329 |
A | ANP401 |
A | HOH557 |
A | HOH573 |
A | HOH575 |
A | HOH592 |
A | HOH593 |
A | HOH613 |
A | HOH648 |
A | HOH653 |
A | HOH712 |
A | HOH729 |
A | HOH737 |
A | HOH830 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG A 403 |
Chain | Residue |
A | ASP321 |
A | ASN323 |
A | ANP401 |
A | HOH738 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG A 404 |
Chain | Residue |
A | ASP309 |
A | ASP321 |
A | ANP401 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 405 |
Chain | Residue |
A | SER68 |
A | PHE70 |
A | ILE73 |
A | HOH657 |
A | HOH695 |
A | HOH777 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 406 |
Chain | Residue |
A | HOH560 |
A | HOH573 |
A | HOH628 |
A | HOH653 |
A | HOH686 |
A | HOH776 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T9C, ECO:0007744|PDB:3T9D, ECO:0007744|PDB:3T9E, ECO:0007744|PDB:3T9F |
Chain | Residue | Details |
A | LYS53 | |
A | LYS248 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T54, ECO:0007744|PDB:3T7A, ECO:0007744|PDB:3T99, ECO:0007744|PDB:3T9A, ECO:0007744|PDB:3T9B, ECO:0007744|PDB:3T9C, ECO:0007744|PDB:3T9D, ECO:0007744|PDB:3T9E, ECO:0007744|PDB:3T9F |
Chain | Residue | Details |
A | ARG134 | |
A | LYS187 | |
A | HIS194 | |
A | GLU237 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T9A, ECO:0007744|PDB:3T9B, ECO:0007744|PDB:3T9C, ECO:0007744|PDB:3T9D |
Chain | Residue | Details |
A | ARG213 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T54, ECO:0007744|PDB:3T9A, ECO:0007744|PDB:3T9B, ECO:0007744|PDB:3T9C, ECO:0007744|PDB:3T9D |
Chain | Residue | Details |
A | ASP246 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T9C, ECO:0007744|PDB:3T9E, ECO:0007744|PDB:3T9F |
Chain | Residue | Details |
A | ARG262 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T54, ECO:0007744|PDB:3T7A |
Chain | Residue | Details |
A | SER264 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T54, ECO:0007744|PDB:3T7A, ECO:0007744|PDB:3T99, ECO:0007744|PDB:3T9B, ECO:0007744|PDB:3T9C, ECO:0007744|PDB:3T9D, ECO:0007744|PDB:3T9E, ECO:0007744|PDB:3T9F |
Chain | Residue | Details |
A | ASP309 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T54 |
Chain | Residue | Details |
A | ASP321 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T9D, ECO:0007744|PDB:3T9E |
Chain | Residue | Details |
A | SER326 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER223 |