4HM0

Naphthalene 1,2-Dioxygenase bound to indole-3-acetate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0016491	molecular_function	oxidoreductase activity
A	0018625	molecular_function	naphthalene 1,2-dioxygenase activity
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051537	molecular_function	2 iron, 2 sulfur cluster binding
B	0016491	molecular_function	oxidoreductase activity
B	0019380	biological_process	3-phenylpropionate catabolic process
B	0051213	molecular_function	dioxygenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO A 501

Chain	Residue
A	LEU31
A	GLN377
A	PHE35
A	ALA36
A	MET59
A	GLY60
A	ILE61
A	ASP62
A	PHE152
A	TYR376

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO A 502

Chain	Residue
A	HIS18
A	CYS81
A	ARG82
A	SER381
A	ASP382
A	LEU383
A	HOH783
A	HOH807
A	HOH808

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 503

Chain	Residue
A	GLU24
A	LYS374
A	HOH809
A	HOH810

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE A 504

Chain	Residue
A	HIS208
A	HIS213
A	ASP362
A	IAC505

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE IAC A 505

Chain	Residue
A	ASN201
A	ASP205
A	HIS208
A	HIS213
A	HIS295
A	ASN297
A	PHE352
A	ASP362
A	FE504

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 506

Chain	Residue
A	TRP439
A	HOH671
A	HOH712

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 507

Chain	Residue
A	LEU128
A	ASN129
A	LYS130
A	LYS131

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FES A 508

Chain	Residue
A	CYS81
A	HIS83
A	ARG84
A	CYS101
A	HIS104
A	TRP106

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 509

Chain	Residue
A	VAL183
A	ARG342
A	ASP346
A	HOH724

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 510

Chain	Residue
A	THR56
A	GLU92
A	PRO186
A	LYS188
A	TRP327
B	GLU570
B	ARG683

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 511

Chain	Residue
A	ASP361
A	ASP364
A	HOH603
A	HOH816
A	HOH857
B	TRP608
B	GLY609
B	ARG648

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 512

Chain	Residue
A	GLU142
A	SER143
A	EDO513

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 513

Chain	Residue
A	SER73
A	ILE74
A	SER143
A	EDO512
A	HOH874

---

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 514

Chain	Residue
A	ASP396
A	ALA397
A	VAL398
A	PRO400
A	HIS440
A	HOH716
A	HOH811

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 515

Chain	Residue
A	PRO337
A	GLU338
A	HOH688

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 701

Chain	Residue
B	ASP546
B	ARG615
B	PHE616
B	EDO705
B	HOH851

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 702

Chain	Residue
B	GLY559
B	SER560
B	GLY666
B	GLU667
B	LYS672
B	HOH914

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 703

Chain	Residue
B	VAL692
B	PHE693
B	HOH841
B	HOH884
B	TYR588
B	MET691

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 704

Chain	Residue
B	ASN591
B	GLN594
B	HOH840
B	HOH904

---

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 705

Chain	Residue
B	ARG638
B	ALA658
B	GLU660
B	VAL678
B	ASP679
B	EDO701
B	HOH868

---

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 706

Chain	Residue
A	VAL190
B	GLN686
B	THR687
B	HIS688

---

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 707

Chain	Residue
B	THR535
B	THR539
B	ILE620
B	THR621
B	ASN622

---

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 708

Chain	Residue
B	LYS632
B	ARG665
B	ARG665
B	GLY669
B	ARG671
B	HOH899

---

Functional Information from PROSITE/UniProt

site_id	PS00570
Number of Residues	24
Details	RING_HYDROXYL_ALPHA Bacterial ring hydroxylating dioxygenases alpha-subunit signature. CrHRGktlvsveaGNakgfvCsYH

Chain	Residue	Details
A	CYS81-HIS104

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	98
Details	Domain: {"description":"Rieske","evidences":[{"source":"PROSITE-ProRule","id":"PRU00628","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16980501","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"OCT-2012","submissionDatabase":"PDB data bank","title":"Naphthalene 1,2-Dioxygenase bound to thioanisole.","authors":["Ferraro D.J.","Ramaswamy S."]}},{"source":"PDB","id":"2HMJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HMK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HML","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HMM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HMN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HMO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HJL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HKV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HM0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HM1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HM5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HM6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HM7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HM8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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