4HL4

Crystal structure of the human TBC1D20 RabGAP domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005096	molecular_function	GTPase activator activity
A	0016192	biological_process	vesicle-mediated transport
A	0043547	biological_process	positive regulation of GTPase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BEF A 401

Chain	Residue
A	ASN75
A	ARG105
A	LYS168
A	HIS172
A	HOH520

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT A 402

Chain	Residue
A	HIS276
A	HIS277

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT A 403

Chain	Residue
A	SER280
A	PHE216
A	SER219

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	186
Details	Domain: {"description":"Rab-GAP TBC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00163","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Arginine finger","evidences":[{"source":"PubMed","id":"23236136","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Glutamine finger","evidences":[{"source":"PubMed","id":"23236136","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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