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4HKF

Crystal structure of Danio rerio MEC-17 catalytic domain in complex with acetyl-CoA

Functional Information from GO Data
ChainGOidnamespacecontents
A0005874cellular_componentmicrotubule
A0019799molecular_functiontubulin N-acetyltransferase activity
A0071929biological_processalpha-tubulin acetylation
Functional Information from PDB Data
site_idAC1
Number of Residues35
DetailsBINDING SITE FOR RESIDUE ACO A 201
ChainResidue
AGLN53
AHIS127
AGLY128
ATYR129
AGLY130
ASER131
AASP151
AARG152
APRO153
ASER154
ALYS156
ALYS96
APHE157
ASER159
APHE160
ALYS163
ASO4202
AHOH301
AHOH302
AHOH331
AHOH366
AHOH380
AVAL115
AHOH391
AHOH406
AHOH419
AHOH432
AHOH467
AHOH481
AASP117
APHE118
ATYR119
AVAL120
AGLN125
AARG126

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 202
ChainResidue
AARG69
AARG126
ALYS163
AACO201
AHOH536

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 203
ChainResidue
AASP6
AGLY82
AGLY83
AHOH519
AHOH542

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 204
ChainResidue
APRO4
AASP6
AARG84
AGLN103

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:23105108, ECO:0000269|PubMed:23128673
ChainResidueDetails
APHE118
ASER154

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Crucial for catalytic activity => ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:23128673
ChainResidueDetails
AGLN53

226707

PDB entries from 2024-10-30

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