4HIB
Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N4-OH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 301 |
| Chain | Residue |
| A | GLU76 |
| A | GLN79 |
| A | LEU80 |
| A | ARG270 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 302 |
| Chain | Residue |
| A | SER205 |
| A | VAL208 |
| A | HOH465 |
| A | HOH466 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 303 |
| Chain | Residue |
| B | GLY240 |
| A | LYS163 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 16B A 304 |
| Chain | Residue |
| A | SER68 |
| A | ASP70 |
| A | LYS92 |
| A | HIS94 |
| A | ASP123 |
| A | LYS125 |
| A | MET182 |
| A | SER183 |
| A | ILE212 |
| A | PRO228 |
| A | GLN241 |
| A | TYR243 |
| A | GLY261 |
| A | ARG262 |
| A | HOH406 |
| A | HOH420 |
| B | ASP128 |
| B | ILE129 |
| B | THR132 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE 16B B 301 |
| Chain | Residue |
| A | ASP128 |
| A | ILE129 |
| A | THR132 |
| B | SER68 |
| B | ASP70 |
| B | LYS92 |
| B | HIS94 |
| B | ASP123 |
| B | LYS125 |
| B | GLU181 |
| B | MET182 |
| B | SER183 |
| B | ILE212 |
| B | PRO228 |
| B | GLN241 |
| B | TYR243 |
| B | GLY261 |
| B | ARG262 |
| B | HOH401 |
| B | HOH407 |
| B | HOH417 |
Functional Information from PROSITE/UniProt
| site_id | PS00156 |
| Number of Residues | 14 |
| Details | OMPDECASE Orotidine 5'-phosphate decarboxylase active site. IFeDrKfaDIGnTV |
| Chain | Residue | Details |
| A | ILE120-VAL133 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"For OMPdecase activity","evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QCD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QCD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QCH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QCL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
