4HGV

Crystal structure of a fumarate hydratase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004333	molecular_function	fumarate hydratase activity
A	0005737	cellular_component	cytoplasm
A	0006099	biological_process	tricarboxylic acid cycle
A	0006106	biological_process	fumarate metabolic process
A	0006108	biological_process	malate metabolic process
A	0016829	molecular_function	lyase activity
B	0003824	molecular_function	catalytic activity
B	0004333	molecular_function	fumarate hydratase activity
B	0005737	cellular_component	cytoplasm
B	0006099	biological_process	tricarboxylic acid cycle
B	0006106	biological_process	fumarate metabolic process
B	0006108	biological_process	malate metabolic process
B	0016829	molecular_function	lyase activity
C	0003824	molecular_function	catalytic activity
C	0004333	molecular_function	fumarate hydratase activity
C	0005737	cellular_component	cytoplasm
C	0006099	biological_process	tricarboxylic acid cycle
C	0006106	biological_process	fumarate metabolic process
C	0006108	biological_process	malate metabolic process
C	0016829	molecular_function	lyase activity
D	0003824	molecular_function	catalytic activity
D	0004333	molecular_function	fumarate hydratase activity
D	0005737	cellular_component	cytoplasm
D	0006099	biological_process	tricarboxylic acid cycle
D	0006106	biological_process	fumarate metabolic process
D	0006108	biological_process	malate metabolic process
D	0016829	molecular_function	lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 501

Chain	Residue
A	THR197
B	ASN151
B	HOH511
B	HOH549
C	LYS334
C	ASN336

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 501

Chain	Residue
D	SER149
D	SER150
D	ASN113
D	MSE114
D	ASN145

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 502

Chain	Residue
A	ASN151
B	THR197
B	HIS198
D	LYS334
D	ASN336

---

Functional Information from PROSITE/UniProt

site_id	PS00163
Number of Residues	10
Details	FUMARATE_LYASES Fumarate lyases signature. GSsiMpGKvN

Chain	Residue	Details
A	GLY327-ASN336

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_00743

Chain	Residue	Details
A	HIS198
B	HIS198
C	HIS198
D	HIS198

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00743

Chain	Residue	Details
A	SER328
B	SER328
C	SER328
D	SER328

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00743

Chain	Residue	Details
A	SER108
B	LYS334
C	SER108
C	SER149
C	THR197
C	SER329
C	LYS334
D	SER108
D	SER149
D	THR197
D	SER329
A	SER149
D	LYS334
A	THR197
A	SER329
A	LYS334
B	SER108
B	SER149
B	THR197
B	SER329

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: in site B => ECO:0000255|HAMAP-Rule:MF_00743

Chain	Residue	Details
A	HIS139
B	HIS139
C	HIS139
D	HIS139

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	SITE: Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_00743

Chain	Residue	Details
A	GLU341
B	GLU341
C	GLU341
D	GLU341

---