4HG9
Crystal structure of AhV_bPA, a basic PLA2 from Agkistrodon halys pallas venom
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0042130 | biological_process | negative regulation of T cell proliferation |
| A | 0050482 | biological_process | arachidonate secretion |
| B | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006644 | biological_process | phospholipid metabolic process |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0042130 | biological_process | negative regulation of T cell proliferation |
| B | 0050482 | biological_process | arachidonate secretion |
| C | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005543 | molecular_function | phospholipid binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006644 | biological_process | phospholipid metabolic process |
| C | 0016042 | biological_process | lipid catabolic process |
| C | 0042130 | biological_process | negative regulation of T cell proliferation |
| C | 0050482 | biological_process | arachidonate secretion |
| D | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0005543 | molecular_function | phospholipid binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0006644 | biological_process | phospholipid metabolic process |
| D | 0016042 | biological_process | lipid catabolic process |
| D | 0042130 | biological_process | negative regulation of T cell proliferation |
| D | 0050482 | biological_process | arachidonate secretion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 201 |
| Chain | Residue |
| A | TYR28 |
| A | GLY30 |
| A | GLY32 |
| A | ASP49 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CIT A 202 |
| Chain | Residue |
| C | HIS1 |
| C | LEU3 |
| C | LYS7 |
| C | ASP72 |
| A | ARG6 |
| A | LYS7 |
| A | LYS10 |
| A | HOH307 |
| A | HOH360 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CIT A 203 |
| Chain | Residue |
| A | HIS1 |
| A | LEU3 |
| A | LYS7 |
| A | ASP72 |
| A | HOH307 |
| A | HOH336 |
| A | HOH378 |
| C | ARG6 |
| C | LYS7 |
| C | LYS10 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE G3P A 204 |
| Chain | Residue |
| A | PHE5 |
| A | GLY30 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 201 |
| Chain | Residue |
| B | TYR28 |
| B | GLY30 |
| B | GLY32 |
| B | ASP49 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 202 |
| Chain | Residue |
| B | ARG6 |
| B | PRO18 |
| B | TYR22 |
| B | ALA23 |
| B | HOH347 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA C 201 |
| Chain | Residue |
| C | TYR28 |
| C | GLY30 |
| C | GLY32 |
| C | ASP49 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE G3P C 202 |
| Chain | Residue |
| C | LEU2 |
| C | PHE5 |
| C | GLY30 |
| C | HIS48 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL C 203 |
| Chain | Residue |
| C | PRO37 |
| C | ASP39 |
| C | ARG43 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 204 |
| Chain | Residue |
| C | ALA101 |
| C | CYS105 |
| C | HOH306 |
| C | HOH332 |
| C | HOH348 |
| C | HOH358 |
| C | HOH364 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA D 201 |
| Chain | Residue |
| D | TYR28 |
| D | GLY30 |
| D | GLY32 |
| D | ASP49 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"P06859","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9761847","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JIA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
