Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4HFI

The GLIC pentameric Ligand-Gated Ion Channel at 2.4 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005267	molecular_function	potassium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0071805	biological_process	potassium ion transmembrane transport
A	1902495	cellular_component	transmembrane transporter complex
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005267	molecular_function	potassium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0071805	biological_process	potassium ion transmembrane transport
B	1902495	cellular_component	transmembrane transporter complex
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005267	molecular_function	potassium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006814	biological_process	sodium ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0071805	biological_process	potassium ion transmembrane transport
C	1902495	cellular_component	transmembrane transporter complex
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005267	molecular_function	potassium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006814	biological_process	sodium ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0071805	biological_process	potassium ion transmembrane transport
D	1902495	cellular_component	transmembrane transporter complex
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005267	molecular_function	potassium channel activity
E	0005272	molecular_function	sodium channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006814	biological_process	sodium ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0035725	biological_process	sodium ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0071805	biological_process	potassium ion transmembrane transport
E	1902495	cellular_component	transmembrane transporter complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 401

Chain	Residue
A	ARG77
A	ILE131
A	GLU181
E	PHE42
E	ARG105

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PLC A 402

Chain	Residue
A	PHE315
A	ARG118
A	PHE121
A	TYR254
A	ASN307

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PLC A 403

Chain	Residue
A	PHE210
A	TRP217

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 405

Chain	Residue
A	PHE78
A	ARG85
A	HOH502

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 406

Chain	Residue
A	ASN139
A	LEU180
A	HOH604
D	ALA175

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 407

Chain	Residue
A	ALA175
D	ASN139
D	LEU180

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 408

Chain	Residue
A	PRO68
A	ILE71
A	ILE73

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 410

Chain	Residue
A	ILE73
A	PRO74
A	ILE76
A	ARG85
A	TYR102

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT A 411

Chain	Residue
C	LMT408
E	LMT408

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 401

Chain	Residue
A	PHE42
A	ARG105
B	ARG77
B	ILE131
B	GLU181

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PLC B 402

Chain	Residue
B	ARG118
B	PHE121
B	TYR254
B	ASN307
B	PHE315

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PLC B 403

Chain	Residue
B	PHE210
B	TRP217
C	TYR278

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 405

Chain	Residue
B	PHE78
B	ARG85
B	HOH502

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA B 406

Chain	Residue
B	PRO68
B	ILE71
B	TRP72
B	ILE73

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 407

Chain	Residue
B	ILE73
B	PRO74
B	ILE76
B	ARG85
B	TYR102

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT B 408

Chain	Residue
A	ALA237
B	ALA237

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT C 401

Chain	Residue
B	PHE42
B	ARG105
C	ARG77
C	ILE131
C	GLU181

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PLC C 402

Chain	Residue
C	ARG118
C	PHE121
C	TYR254
C	ASN307
C	PHE315

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PLC C 403

Chain	Residue
C	PHE210
C	TRP217
D	PHE267
D	TYR278

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 405

Chain	Residue
C	PHE78
C	ARG85
C	HOH502

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA C 406

Chain	Residue
C	PRO68
C	ILE71
C	ILE73

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT C 407

Chain	Residue
C	ILE73
C	PRO74
C	ILE76
C	ARG85
C	TYR102

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT C 408

Chain	Residue
A	LMT411

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT D 401

Chain	Residue
C	PHE42
C	ARG105
D	ARG77
D	ILE131
D	GLU181

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PLC D 402

Chain	Residue
D	ARG118
D	PHE121
D	TYR254
D	ASN307
D	PHE315

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PLC D 403

Chain	Residue
D	PHE210
D	TRP217
E	TYR278

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 405

Chain	Residue
D	ARG85
D	HOH552
D	PHE78

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA D 406

Chain	Residue
D	VAL5
D	ILE71
D	ILE73

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT D 407

Chain	Residue
D	ILE73
D	PRO74
D	ILE76
D	ARG85
D	TYR102

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT E 401

Chain	Residue
D	PHE42
D	ARG105
E	ARG77
E	ILE131
E	GLU181

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PLC E 402

Chain	Residue
E	ARG118
E	PHE121
E	TYR254
E	ASN307
E	PHE315

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PLC E 403

Chain	Residue
A	PHE267
A	TYR278
E	PHE210
E	TRP217

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 405

Chain	Residue
E	PHE78
E	ARG85
E	HOH502

site_id	DC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA E 406

Chain	Residue
E	PRO68
E	ILE71
E	ILE73

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT E 407

Chain	Residue
E	PRO74
E	ILE76
E	ARG85
E	TYR102

site_id	DC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT E 408

Chain	Residue
A	LMT411

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	990
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
A	GLN2-GLN193
E	ASN245-MET252
A	ASN245-MET252
B	GLN2-GLN193
B	ASN245-MET252
C	GLN2-GLN193
C	ASN245-MET252
D	GLN2-GLN193
D	ASN245-MET252
E	GLN2-GLN193

site_id	SWS_FT_FI2
Number of Residues	530
Details	TRANSMEM: Helical

Chain	Residue	Details
A	TYR194-PHE216
C	SER220-THR244
C	THR253-VAL281
C	PRO285-PHE317
D	TYR194-PHE216
D	SER220-THR244
D	THR253-VAL281
D	PRO285-PHE317
E	TYR194-PHE216
E	SER220-THR244
E	THR253-VAL281
A	SER220-THR244
E	PRO285-PHE317
A	THR253-VAL281
A	PRO285-PHE317
B	TYR194-PHE216
B	SER220-THR244
B	THR253-VAL281
B	PRO285-PHE317
C	TYR194-PHE216

site_id	SWS_FT_FI3
Number of Residues	20
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	TRP217-THR219
E	GLU282-GLN284
A	GLU282-GLN284
B	TRP217-THR219
B	GLU282-GLN284
C	TRP217-THR219
C	GLU282-GLN284
D	TRP217-THR219
D	GLU282-GLN284
E	TRP217-THR219

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)