Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4HE8

Crystal structure of the membrane domain of respiratory complex I from Thermus thermophilus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
A	0030964	cellular_component	NADH dehydrogenase complex
A	0048038	molecular_function	quinone binding
A	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
A	0055085	biological_process	transmembrane transport
B	0005886	cellular_component	plasma membrane
B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
B	0030964	cellular_component	NADH dehydrogenase complex
B	0048038	molecular_function	quinone binding
B	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
B	0055085	biological_process	transmembrane transport
C	0003954	molecular_function	NADH dehydrogenase activity
C	0005886	cellular_component	plasma membrane
C	0009060	biological_process	aerobic respiration
C	0016020	cellular_component	membrane
C	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
C	0045272	cellular_component	plasma membrane respiratory chain complex I
C	0048038	molecular_function	quinone binding
D	0005886	cellular_component	plasma membrane
D	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D	0048038	molecular_function	quinone binding
D	0055085	biological_process	transmembrane transport
E	0005886	cellular_component	plasma membrane
E	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
E	0030964	cellular_component	NADH dehydrogenase complex
E	0042773	biological_process	ATP synthesis coupled electron transport
E	0048038	molecular_function	quinone binding
E	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
F	0003954	molecular_function	NADH dehydrogenase activity
F	0005886	cellular_component	plasma membrane
F	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
F	0015990	biological_process	electron transport coupled proton transport
F	0042773	biological_process	ATP synthesis coupled electron transport
F	0045272	cellular_component	plasma membrane respiratory chain complex I
F	0048038	molecular_function	quinone binding
G	0003954	molecular_function	NADH dehydrogenase activity
G	0005886	cellular_component	plasma membrane
G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
G	0009060	biological_process	aerobic respiration
G	0015990	biological_process	electron transport coupled proton transport
G	0042773	biological_process	ATP synthesis coupled electron transport
G	0045272	cellular_component	plasma membrane respiratory chain complex I
G	0048038	molecular_function	quinone binding
G	0048039	molecular_function	ubiquinone binding
H	0003954	molecular_function	NADH dehydrogenase activity
H	0005886	cellular_component	plasma membrane
H	0009060	biological_process	aerobic respiration
H	0016020	cellular_component	membrane
H	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
H	0045272	cellular_component	plasma membrane respiratory chain complex I
H	0048038	molecular_function	quinone binding
I	0005886	cellular_component	plasma membrane
I	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
I	0042773	biological_process	ATP synthesis coupled electron transport
I	0048038	molecular_function	quinone binding
I	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
I	0055085	biological_process	transmembrane transport
J	0005886	cellular_component	plasma membrane
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0048038	molecular_function	quinone binding
J	0055085	biological_process	transmembrane transport
K	0005886	cellular_component	plasma membrane
K	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
K	0030964	cellular_component	NADH dehydrogenase complex
K	0042773	biological_process	ATP synthesis coupled electron transport
K	0048038	molecular_function	quinone binding
K	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
L	0003954	molecular_function	NADH dehydrogenase activity
L	0005886	cellular_component	plasma membrane
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0015990	biological_process	electron transport coupled proton transport
L	0042773	biological_process	ATP synthesis coupled electron transport
L	0045272	cellular_component	plasma membrane respiratory chain complex I
L	0048038	molecular_function	quinone binding
M	0003954	molecular_function	NADH dehydrogenase activity
M	0005886	cellular_component	plasma membrane
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0009060	biological_process	aerobic respiration
M	0015990	biological_process	electron transport coupled proton transport
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0045272	cellular_component	plasma membrane respiratory chain complex I
M	0048038	molecular_function	quinone binding
M	0048039	molecular_function	ubiquinone binding
N	0005886	cellular_component	plasma membrane
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0042773	biological_process	ATP synthesis coupled electron transport
N	0048038	molecular_function	quinone binding
N	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
N	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE UMQ J 200

Chain	Residue
A	LEU102
N	ALA7
N	VAL11
N	PHE50
N	GLY51
D	LYS120
J	GLY133
J	ASP134
J	TRP135
J	LEU136
J	PHE137
J	LEU140
J	PHE144

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE UMQ L 700

Chain	Residue
L	GLY18
L	LYS22
L	GLY100
L	SER102
L	ARG103
L	TYR107
L	TYR146
M	PRO352
M	GLY353
M	ALA356

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE UMQ D 200

Chain	Residue
B	LEU102
D	GLY133
D	ASP134
D	TRP135
D	LEU136
D	PHE137
D	LEU140
D	PHE144
I	ALA7
I	VAL11
I	PHE50
I	GLY51

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE UMQ F 700

Chain	Residue
F	GLY18
F	LYS22
F	GLY100
F	SER102
F	ARG103
F	TYR107
F	TYR146
G	PRO352
G	ALA356

Functional Information from PROSITE/UniProt

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpLaDAIKSIfKE

Chain	Residue	Details
H	GLY55-GLU70

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLPEAEqeLVg.G

Chain	Residue	Details
H	PRO218-GLY231

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	360
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
H	TRP11-MET31
H	PHE80-ILE100
H	LEU120-GLY140
H	ALA157-VAL177
H	HIS192-ALA212
H	PHE252-LEU272
H	GLU273-ILE293
H	TRP310-LEU330
H	TYR336-PRO356
C	TRP11-MET31
C	PHE80-ILE100
C	LEU120-GLY140
C	ALA157-VAL177
C	HIS192-ALA212
C	PHE252-LEU272
C	GLU273-ILE293
C	TRP310-LEU330
C	TYR336-PRO356
I	LEU104-TRP124
I	PHE137-ALA157
I	TYR172-PHE192
I	PRO204-LEU224
I	PRO230-ALA250
I	LEU257-ASN277
I	ALA280-SER300
I	LEU322-PHE342
I	VAL360-LEU380
I	ALA400-LEU420
F	PHE397-ALA417
F	VAL441-LEU461
F	GLY492-PHE512
F	GLY584-MET604

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)