Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004450 | molecular_function | isocitrate dehydrogenase (NADP+) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006097 | biological_process | glyoxylate cycle |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006102 | biological_process | isocitrate metabolic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004450 | molecular_function | isocitrate dehydrogenase (NADP+) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006097 | biological_process | glyoxylate cycle |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006102 | biological_process | isocitrate metabolic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 501 |
| Chain | Residue |
| A | ASP278 |
| A | ASP282 |
| A | HOH708 |
| B | ASP255 |
| B | HOH604 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NDP A 502 |
| Chain | Residue |
| A | THR80 |
| A | ARG85 |
| A | GLU309 |
| A | HIS312 |
| A | GLY313 |
| A | THR314 |
| A | VAL315 |
| A | THR316 |
| A | ARG317 |
| A | HIS318 |
| A | THR330 |
| A | ASN331 |
| A | HOH608 |
| A | HOH610 |
| A | HOH612 |
| A | HOH724 |
| A | HOH754 |
| A | LYS75 |
| A | ALA77 |
| A | THR78 |
| A | ILE79 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 503 |
| Chain | Residue |
| A | GLY139 |
| A | ARG143 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 501 |
| Chain | Residue |
| A | ASP255 |
| A | HOH607 |
| B | ASP278 |
| B | ASP282 |
| B | HOH720 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NDP B 502 |
| Chain | Residue |
| B | LYS75 |
| B | ALA77 |
| B | THR78 |
| B | THR80 |
| B | ARG85 |
| B | ASN99 |
| B | GLU309 |
| B | HIS312 |
| B | GLY313 |
| B | THR314 |
| B | VAL315 |
| B | THR316 |
| B | HIS318 |
| B | THR330 |
| B | ASN331 |
| B | HOH606 |
| B | HOH686 |
| B | HOH702 |
| B | HOH707 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 503 |
| Chain | Residue |
| B | PHE138 |
| B | GLY139 |
| B | ARG143 |
| B | HOH658 |
Functional Information from PROSITE/UniProt
| site_id | PS00470 |
| Number of Residues | 20 |
| Details | IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NYDGDVqSDtvAqgy.GSLGL |
| Chain | Residue | Details |
| A | ASN274-LEU293 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23409873","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HCX","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Site: {"description":"Critical for catalysis","evidences":[{"source":"UniProtKB","id":"P08200","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"28250431","evidenceCode":"ECO:0000269"}]} |
