4HAT

Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1-Ran-RanBP1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000054	biological_process	ribosomal subunit export from nucleus
A	0000055	biological_process	ribosomal large subunit export from nucleus
A	0000056	biological_process	ribosomal small subunit export from nucleus
A	0000070	biological_process	mitotic sister chromatid segregation
A	0000166	molecular_function	nucleotide binding
A	0000278	biological_process	mitotic cell cycle
A	0000287	molecular_function	magnesium ion binding
A	0000785	cellular_component	chromatin
A	0001673	cellular_component	male germ cell nucleus
A	0002177	cellular_component	manchette
A	0003682	molecular_function	chromatin binding
A	0003723	molecular_function	RNA binding
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005049	molecular_function	nuclear export signal receptor activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005643	cellular_component	nuclear pore
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005814	cellular_component	centriole
A	0005829	cellular_component	cytosol
A	0006096	biological_process	glycolytic process
A	0006259	biological_process	DNA metabolic process
A	0006606	biological_process	protein import into nucleus
A	0006611	biological_process	protein export from nucleus
A	0006913	biological_process	nucleocytoplasmic transport
A	0007052	biological_process	mitotic spindle organization
A	0007286	biological_process	spermatid development
A	0008104	biological_process	protein localization
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0016032	biological_process	viral process
A	0016787	molecular_function	hydrolase activity
A	0019003	molecular_function	GDP binding
A	0019904	molecular_function	protein domain specific binding
A	0021766	biological_process	hippocampus development
A	0030036	biological_process	actin cytoskeleton organization
A	0030496	cellular_component	midbody
A	0031503	biological_process	protein-containing complex localization
A	0032991	cellular_component	protein-containing complex
A	0035281	biological_process	pre-miRNA export from nucleus
A	0036126	cellular_component	sperm flagellum
A	0042307	biological_process	positive regulation of protein import into nucleus
A	0042470	cellular_component	melanosome
A	0042565	cellular_component	RNA nuclear export complex
A	0044877	molecular_function	protein-containing complex binding
A	0045296	molecular_function	cadherin binding
A	0045505	molecular_function	dynein intermediate chain binding
A	0046039	biological_process	GTP metabolic process
A	0046872	molecular_function	metal ion binding
A	0046982	molecular_function	protein heterodimerization activity
A	0051301	biological_process	cell division
A	0055037	cellular_component	recycling endosome
A	0061015	biological_process	snRNA import into nucleus
A	0061676	molecular_function	importin-alpha family protein binding
A	0070062	cellular_component	extracellular exosome
A	0070883	molecular_function	pre-miRNA binding
A	0071389	biological_process	cellular response to mineralocorticoid stimulus
A	0090543	cellular_component	Flemming body
A	1902570	biological_process	protein localization to nucleolus
B	0006913	biological_process	nucleocytoplasmic transport
B	0046907	biological_process	intracellular transport
C	0000055	biological_process	ribosomal large subunit export from nucleus
C	0000056	biological_process	ribosomal small subunit export from nucleus
C	0000776	cellular_component	kinetochore
C	0005049	molecular_function	nuclear export signal receptor activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005816	cellular_component	spindle pole body
C	0006406	biological_process	mRNA export from nucleus
C	0006409	biological_process	tRNA export from nucleus
C	0006611	biological_process	protein export from nucleus
C	0006886	biological_process	intracellular protein transport
C	0015031	biological_process	protein transport
C	0017070	molecular_function	U6 snRNA binding
C	0030619	molecular_function	U1 snRNA binding
C	0030620	molecular_function	U2 snRNA binding
C	0030621	molecular_function	U4 snRNA binding
C	0030623	molecular_function	U5 snRNA binding
C	0031267	molecular_function	small GTPase binding
C	0034501	biological_process	protein localization to kinetochore
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0051168	biological_process	nuclear export
C	0051170	biological_process	import into nucleus
C	0061608	molecular_function	nuclear import signal receptor activity
C	0071528	biological_process	tRNA re-export from nucleus

Functional Information from PDB Data

site_id	AC1
Number of Residues	30
Details	BINDING SITE FOR RESIDUE GNP A 301

Chain	Residue
A	GLY19
A	LYS37
A	LYS38
A	TYR39
A	ALA41
A	THR42
A	GLY68
A	GLN69
A	ASN122
A	LYS123
A	ASP125
A	GLY20
A	ILE126
A	SER150
A	ALA151
A	LYS152
A	MG302
A	HOH418
A	HOH420
A	HOH493
A	HOH580
A	HOH624
A	THR21
A	HOH625
A	GLY22
A	LYS23
A	THR24
A	THR25
A	PHE35
A	GLU36

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 302

Chain	Residue
A	THR24
A	THR42
A	GNP301
A	HOH624
A	HOH625

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 303

Chain	Residue
A	ASN103
A	ARG106
A	ASP107
A	HOH466

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE LMB C 1101

Chain	Residue
C	LYS525
C	VAL529
C	CYS539
C	VAL540
C	LYS548
C	ALA552
C	ILE555
C	HIS569
C	THR575
C	LYS579
C	HOH1892
C	HOH2126
C	HOH2300
C	HOH2308

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 1102

Chain	Residue
C	TRP500
C	SER501
C	TRP502
C	ASN547

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 1103

Chain	Residue
C	ASN846
C	TRP891
C	HOH1535
C	HOH1989
C	HOH2149
C	HOH2197

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO C 1104

Chain	Residue
C	GLN988
C	SER992

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 1105

Chain	Residue
C	TYR718
C	GLY722
C	VAL786
C	HOH2333

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 1106

Chain	Residue
C	GLU1009
C	HOH1932

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 1107

Chain	Residue
C	LYS605
C	CYS606
C	LYS607
C	TYR608

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 1108

Chain	Residue
C	PRO61
C	GLN62

---

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 1109

Chain	Residue
C	ARG227

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Region: {"description":"Switch-I","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Region: {"description":"Switch-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Region: {"description":"Interaction with RANBP1","evidences":[{"source":"PubMed","id":"7891706","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10078529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10367892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11832950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18611384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19389996","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19505478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24449914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26272610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26349033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28282025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7885480","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10078529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10367892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11832950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19389996","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24449914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26272610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26349033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28282025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7885480","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10078529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10367892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11832950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18611384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19389996","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19505478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24449914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26272610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26349033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28282025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7885480","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10078529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10367892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11832950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18611384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19389996","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19505478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24449914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26272610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26349033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28282025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7885480","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10078529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10367892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11832950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18611384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19389996","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19505478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24449914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26272610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26349033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28282025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7885480","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1K5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Site: {"description":"Essential for GTP hydrolysis","evidences":[{"source":"PubMed","id":"18591255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26272610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8636225","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"31075303","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"29040603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62827","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	66
Details	Domain: {"description":"Importin N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00115","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---