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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4H9M

The first Jack bean urease (Canavalia ensiformis) complex obtained at 1.52 resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009039	molecular_function	urease activity
A	0016151	molecular_function	nickel cation binding
A	0016787	molecular_function	hydrolase activity
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0035550	cellular_component	urease complex
A	0035821	biological_process	modulation of process of another organism
A	0043419	biological_process	urea catabolic process
A	0046872	molecular_function	metal ion binding
A	0090729	molecular_function	toxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI A 901

Chain	Residue
A	HIS407
A	HIS409
A	KCX490
A	ASP633
A	NI902
A	HAE929

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NI A 902

Chain	Residue
A	HIS545
A	GLY550
A	NI901
A	HAE929
A	KCX490
A	HIS492
A	HIS519

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 903

Chain	Residue
A	LEU111
A	PHE112
A	GLY113
A	SER114
A	LEU115
A	HOH1235
A	HOH1643

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 904

Chain	Residue
A	ALA80
A	VAL81
A	GLN82
A	THR740
A	GLU742
A	HOH1644

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 905

Chain	Residue
A	ILE154
A	SER209
A	VAL210
A	THR211
A	EDO919
A	HOH1509
A	HOH1657

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 906

Chain	Residue
A	ARG6
A	LYS10
A	ASN735
A	HOH1180
A	HOH1196

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 907

Chain	Residue
A	PRO72
A	ARG835
A	HOH1100
A	HOH1396

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 908

Chain	Residue
A	PRO373
A	MET376
A	ASN377
A	GLY378
A	VAL379
A	HOH1628

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 909

Chain	Residue
A	ASN225
A	KCX247
A	PRO499
A	HOH1110
A	HOH1303
A	HOH1741

site_id	BC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO A 910

Chain	Residue
A	GLY362
A	LEU702
A	GLY723
A	ALA759
A	LEU760
A	ARG783
A	HOH1314
A	HOH1418
A	HOH1595
A	HOH1603

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 911

Chain	Residue
A	THR350
A	HOH1151
A	HOH1514
A	HOH1631
A	HOH1685
A	HOH1736

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 912

Chain	Residue
A	ALA280
A	ASN281
A	GLU395
A	GLY396
A	HOH1159

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 913

Chain	Residue
A	ARG26
A	GLY27
A	ASP49
A	HOH1564
A	HOH1771

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 914

Chain	Residue
A	MET1
A	LEU3
A	GLY12
A	LEU13
A	PRO743
A	LYS745
A	HOH1214
A	HOH1479

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 915

Chain	Residue
A	ALA196
A	GLY197
A	VAL314
A	LYS319
A	HOH1237
A	HOH1737

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 916

Chain	Residue
A	ALA334
A	GLU480
A	GLU480
A	LYS483
A	HOH1207

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 917

Chain	Residue
A	SER473
A	ALA500
A	ASP503
A	ASN504
A	HOH1858

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 918

Chain	Residue
A	SER120
A	SER258
A	HOH1472

site_id	CC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 919

Chain	Residue
A	ARG102
A	ASN104
A	GLY105
A	GLU106
A	SER209
A	EDO905
A	HOH1599

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 920

Chain	Residue
A	HOH1425
A	HOH1712

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 921

Chain	Residue
A	GLY317
A	HIS593
A	PHE605
A	HOH1376
A	HOH1581
A	HOH1909

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 922

Chain	Residue
A	ASN218
A	HOH1384
A	HOH1500
A	HOH1855

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 923

Chain	Residue
A	LEU770
A	VAL784
A	GLU785
A	HOH1124
A	HOH1355
A	HOH1429

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 924

Chain	Residue
A	ILE335
A	LYS360
A	ALA365
A	ASN382
A	HOH1896

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 925

Chain	Residue
A	ASP810
A	SER813
A	THR815
A	HOH1959

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 926

Chain	Residue
A	GLY316
A	GLY317
A	ASP494
A	HIS593
A	HOH1581
A	HOH1658

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 927

Chain	Residue
A	HIS511
A	HOH1325
A	HOH1540

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 928

Chain	Residue
A	GLY538
A	THR540
A	LYS792
A	LEU793

site_id	DC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HAE A 929

Chain	Residue
A	HIS407
A	ALA440
A	KCX490
A	HIS492
A	HIS519
A	HIS545
A	GLY550
A	ASP633
A	NI901
A	NI902

site_id	DC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 930

Chain	Residue
A	THR339
A	THR432
A	GLN449
A	GLY724
A	MET725
A	VAL726
A	HOH1618

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 931

Chain	Residue
A	ARG132
A	ASN297
A	HOH1257
A	HOH1700

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 932

Chain	Residue
A	VAL232
A	ASN233
A	GLU234
A	HOH1841

Functional Information from PROSITE/UniProt

site_id	PS00145
Number of Residues	17
Details	UREASE_2 Urease active site. MVCHHLdreIpeDLaFA

Chain	Residue	Details
A	MET590-ALA606

site_id	PS01120
Number of Residues	14
Details	UREASE_1 Urease nickel ligands signature. TAGAIDcHVHyicP

Chain	Residue	Details
A	THR400-PRO413

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250

Chain	Residue	Details
A	HIS593

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269\|PubMed:20471401, ECO:0007744\|PDB:3LA4, ECO:0007744\|PDB:4GOA, ECO:0007744\|PDB:4GY7, ECO:0007744\|PDB:4H9M

Chain	Residue	Details
A	HIS407
A	HIS409
A	HIS519
A	HIS545
A	ASP633

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: via carbamate group => ECO:0000269\|PubMed:20471401, ECO:0007744\|PDB:3LA4, ECO:0007744\|PDB:4GOA, ECO:0007744\|PDB:4GY7, ECO:0007744\|PDB:4H9M

Chain	Residue	Details
A	KCX490

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	HIS492

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-carboxylysine => ECO:0000269\|PubMed:20471401

Chain	Residue	Details
A	KCX490

235183

PDB entries from 2025-04-23

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