4H4M

Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003964	molecular_function	RNA-directed DNA polymerase activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0006278	biological_process	RNA-templated DNA biosynthetic process
B	0003964	molecular_function	RNA-directed DNA polymerase activity
B	0006278	biological_process	RNA-templated DNA biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 494 A 601

Chain	Residue
A	PRO95
A	TYR188
A	LYS223
A	TRP229
A	PRO236
A	TYR318
A	LEU100
A	LYS101
A	LYS102
A	LYS103
A	VAL106
A	VAL108
A	VAL179
A	TYR181

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	380
Details	Domain: {"description":"Reverse transcriptase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"}]}

Chain

Residue

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Region: {"description":"RT 'primer grip'"}

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Residue

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site_id	SWS_FT_FI3
Number of Residues	32
Details	Motif: {"description":"Tryptophan repeat motif"}

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Residue

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site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {}

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Residue

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site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

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Residue

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site_id	SWS_FT_FI6
Number of Residues	4
Details	Site: {"description":"Essential for RT p66/p51 heterodimerization"}

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Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	1
Details	Site: {"description":"Cleavage; by viral protease; partial"}

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Details

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