Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | HIS226 |
| A | HIS230 |
| A | HIS236 |
| A | 10B306 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 302 |
| Chain | Residue |
| A | HIS175 |
| A | ASP177 |
| A | HIS190 |
| A | HIS203 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 303 |
| Chain | Residue |
| A | GLY183 |
| A | ASP185 |
| A | LEU187 |
| A | ASP205 |
| A | GLU208 |
| A | ASP182 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 304 |
| Chain | Residue |
| A | ASP131 |
| A | ASP206 |
| A | GLU208 |
| A | HOH452 |
| A | HOH453 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 305 |
| Chain | Residue |
| A | ASP165 |
| A | GLY197 |
| A | GLN199 |
| A | ASP201 |
| A | HOH406 |
| A | HOH411 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 10B A 306 |
| Chain | Residue |
| A | GLY186 |
| A | LEU187 |
| A | LEU188 |
| A | ALA189 |
| A | LEU222 |
| A | HIS226 |
| A | GLU227 |
| A | HIS230 |
| A | HIS236 |
| A | LEU243 |
| A | TYR245 |
| A | MET247 |
| A | ZN301 |
| A | HOH415 |
| A | HOH492 |
| B | TYR245 |
| B | PRO246 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 307 |
| Chain | Residue |
| A | PRO254 |
| A | HOH421 |
| B | PRO254 |
| B | PRO255 |
| B | HOH448 |
| B | HOH451 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 308 |
| Chain | Residue |
| A | ASP177 |
| A | GLY178 |
| A | GOL311 |
| A | HOH476 |
| A | HOH515 |
| A | HOH553 |
| A | HOH559 |
| A | HOH560 |
| A | HOH590 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 309 |
| Chain | Residue |
| A | TYR179 |
| A | LEU187 |
| A | HIS190 |
| A | HOH594 |
| A | HOH595 |
| B | PRO240 |
| B | TYR245 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PGO A 310 |
| Chain | Residue |
| A | ALA173 |
| A | GLU174 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 311 |
| Chain | Residue |
| A | GOL308 |
| A | HOH480 |
| A | HOH515 |
| A | HOH529 |
| A | HOH553 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 312 |
| Chain | Residue |
| A | ASN120 |
| A | THR122 |
| A | THR157 |
| A | HOH536 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 313 |
| Chain | Residue |
| A | HOH434 |
| A | HOH483 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 301 |
| Chain | Residue |
| B | HIS226 |
| B | HIS230 |
| B | HIS236 |
| B | 10B306 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 302 |
| Chain | Residue |
| B | HIS175 |
| B | ASP177 |
| B | HIS190 |
| B | HIS203 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 303 |
| Chain | Residue |
| B | ASP182 |
| B | GLY183 |
| B | ASP185 |
| B | LEU187 |
| B | ASP205 |
| B | GLU208 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 304 |
| Chain | Residue |
| B | ASP131 |
| B | ASP206 |
| B | GLU208 |
| B | HOH468 |
| B | HOH529 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 305 |
| Chain | Residue |
| B | ASP201 |
| B | HOH401 |
| B | HOH405 |
| B | ASP165 |
| B | GLY197 |
| B | GLN199 |
| site_id | CC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 10B B 306 |
| Chain | Residue |
| A | TYR245 |
| A | PRO246 |
| A | MET247 |
| B | GLY186 |
| B | LEU187 |
| B | LEU188 |
| B | ALA189 |
| B | LEU222 |
| B | HIS226 |
| B | GLU227 |
| B | HIS230 |
| B | HIS236 |
| B | LEU243 |
| B | TYR245 |
| B | MET247 |
| B | TYR248 |
| B | ZN301 |
| B | HOH444 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 307 |
| Chain | Residue |
| B | PHE250 |
| B | THR251 |
| B | HOH423 |
| B | HOH515 |
| B | HOH546 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 308 |
| Chain | Residue |
| B | PEG309 |
| B | HOH442 |
| B | HOH443 |
| B | HOH480 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG B 309 |
| Chain | Residue |
| B | TYR179 |
| B | PEG308 |
| B | HOH442 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHAL |
| Chain | Residue | Details |
| A | VAL223-LEU232 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| B | GLU227 | |
| A | GLU227 | |
| Chain | Residue | Details |
| A | ASP185 | |
| A | LEU187 | |
| A | GLY197 | |
| A | GLN199 | |
| A | ASP201 | |
| A | ASP205 | |
| A | ASP206 | |
| A | GLU208 | |
| B | ASP131 | |
| B | ASP165 | |
| B | ASP182 | |
| B | GLY183 | |
| B | ASP185 | |
| B | LEU187 | |
| B | GLY197 | |
| B | GLN199 | |
| B | ASP201 | |
| B | ASP205 | |
| B | ASP206 | |
| B | GLU208 | |
| A | ASP131 | |
| A | ASP165 | |
| A | ASP182 | |
| A | GLY183 | |
| Chain | Residue | Details |
| A | HIS236 | |
| B | HIS175 | |
| B | ASP177 | |
| B | HIS190 | |
| B | HIS203 | |
| B | HIS226 | |
| B | HIS230 | |
| B | HIS236 | |
| A | HIS175 | |
| A | ASP177 | |
| A | HIS190 | |
| A | HIS203 | |
| A | HIS226 | |
| A | HIS230 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN127 | |
| B | ASN120 | |
| B | ASN127 | |
| A | ASN120 | |
