4H3S

The Structure of Glutaminyl-tRNA Synthetase from Saccharomyces Cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003729	molecular_function	mRNA binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004819	molecular_function	glutamine-tRNA ligase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006412	biological_process	translation
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006425	biological_process	glutaminyl-tRNA aminoacylation
A	0008270	molecular_function	zinc ion binding
A	0016874	molecular_function	ligase activity
A	0043039	biological_process	tRNA aminoacylation
A	1990825	molecular_function	sequence-specific mRNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 901

Chain	Residue
A	CYS346
A	CYS348
A	CYS372
A	HIS374

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 902

Chain	Residue
A	HOH1024
A	HOH1078
A	HOH1150
A	PHE256
A	HIS268
A	ALA271
A	GOL903
A	BR910

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 903

Chain	Residue
A	HIS265
A	GLY267
A	HIS268
A	ARG488
A	LEU489
A	GOL902

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 904

Chain	Residue
A	LEU574
A	VAL781
A	ARG799
A	HOH1289

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 905

Chain	Residue
A	SER324
A	ASP325
A	PHE327
A	ASP328
A	GLU329
A	THR430
A	LYS433
A	TRP434
A	GOL909
A	HOH1181

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 906

Chain	Residue
A	HIS444
A	PHE462
A	SER465
A	GLN483
A	HOH1335
A	HOH1408

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 907

Chain	Residue
A	ASP292
A	ASN294
A	PRO295
A	GLU296
A	PHE303
A	HIS427
A	PRO428
A	ARG429
A	HOH1325
A	HOH1435

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 908

Chain	Residue
A	SER378
A	GLU380
A	ASN583
A	SER585
A	HOH1029
A	HOH1053
A	HOH1162

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 909

Chain	Residue
A	ARG387
A	ARG390
A	THR430
A	LYS433
A	GOL905
A	HOH1181
A	HOH1251

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR A 910

Chain	Residue
A	CYS458
A	THR459
A	GOL902

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 911

Chain	Residue
A	PRO728
A	SER730
A	GLU731

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT A 912

Chain	Residue
A	LYS771
A	SER790
A	THR791

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 913

Chain	Residue
A	HIS228
A	LYS229
A	TYR278
A	HIS282
A	HIS455
A	HOH1391

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 914

Chain	Residue
A	TYR263
A	LEU496
A	LYS498
A	THR520
A	HOH1115

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT A 915

Chain	Residue
A	LYS643
A	TYR684
A	HOH1441

---

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DTT A 916

Chain	Residue
A	ARG390
A	ASP391
A	LYS433
A	TRP434
A	ARG435
A	HOH1021
A	HOH1390

---

Functional Information from PROSITE/UniProt

site_id	PS00178
Number of Residues	12
Details	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PepNGyLHIGHS

Chain	Residue	Details
A	PRO258-SER269

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Motif: {"description":"'HIGH' region"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Motif: {"description":"'KMSKS' region"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00962","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---